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High SHC3 expression is associated with glioblastoma.
Rai (ShcC/N-Shc), a member of the family of Shc (显示 SHC1 蛋白)-like adaptor proteins, as a new regulator of migration of normal and cancer stem/progenitor cells.
Polymorphism in RAI (显示 RNH1 蛋白) and CD3EAP (显示 CD3EAP 蛋白) are associated with outcome of myeloma patients treated with high dose treatment.
amplification of SHC3 and EDG3 (显示 S1PR3 蛋白) genes suggests that the two proteins co-operate and are important for ependymomas in vivo.
Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc (显示 SHC1 蛋白).
ALK-ShcC signal activation, possibly caused by co-amplification with the N-myc gene, might give additional effects on malignant tumor progression of neuroblastoma.ShcC is a potent substrate of the activated ALK kinase.
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret (显示 RET 蛋白) to the phosphatidylinositol 3-kinase/Akt (显示 AKT1 蛋白) signaling pathway.
ShcC has phosphotyrosine-dependent and -independent functions in neuroblastoma (显示 ARHGEF16 蛋白) cells
The inappropriate in vivo expression of Shc3 in high-grade glioma may contribute to the survival of the cancer cells.
data suggest that RAI (ShcC/H-Shc (显示 SHC1 蛋白))is a critical substrate for RET (显示 RET 蛋白) oncoproteins in thyroid carcinomas
The results provide evidence that Rai/ShcC plays opposite roles in Th17 cell differentiation and astrocyte activation
Rai interferes with the TCR signaling cascade one of the earliest steps--recruitment of the initiating kinase ZAP-70 (显示 ZAP70 蛋白) to the phosphorylated subunit of the TCR/CD3 (显示 CD3E 蛋白) complex.
TrkB (显示 NTRK2 蛋白)-mediated ERK1/2 activation is impaired in huntingtin (显示 HTT 蛋白) knock-in striatal cells involves reduced p52 (显示 GTF2H4 蛋白)/p46 (显示 POLDIP3 蛋白) Shc (显示 SHC1 蛋白) expression
binds the Trk (显示 NTRK1 蛋白) receptors in a phosphotyrosine-dependent manner via their N-terminal phosphotyrosine binding domain
Rai has a functional neuroprotective role in brain injury, with possible implications in the treatment of stroke
ShcC mediates TrkB (显示 NTRK2 蛋白)-Ras/MAPK (显示 MAPK1 蛋白) signaling & regulates NMDA receptor function in the hippocampus via interaction with phosphotyrosines on the receptor subunits. It serves as a modulator of hippocampal synaptic plasticity underlying learning & memory.
Expressed in T and B cells; loss of Rai results in breaking of immunological tolerance and development of systemic autoimmunity.
may be involved in brain-derived neurotrophic factor signalling during retinal development
SH2 domain protein C3
, SHC-transforming protein 3
, SHC-transforming protein C
, neuronal Shc
, protein Rai
, src homology 2 domain-containing transforming protein C3
, src homology 2 domain-containing-transforming protein C3