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ROR1 (显示 ROR1 蛋白) and ROR2 play distinct roles in endometrial cancer. ROR1 (显示 ROR1 蛋白) may promote tumor progression, while ROR2 may act as a tumor suppressor in endometrioid endometrial cancer.
Wnt5a (显示 WNT5A 蛋白)-Ror2 signaling enhanced tongue SCC (显示 CYP11A1 蛋白) cell aggressiveness and promoted production of MMP-2 (显示 MMP2 蛋白) following DeltaNp63beta-mediated EMT (显示 ITK 蛋白)
In squamous/adenosquamous carcinoma and adenocarcinoma of the gallbladder positive ROR2 or WNT5a (显示 WNT5A 蛋白) expression is generally associated with a poor prognosis.
Wnt5a (显示 WNT5A 蛋白) suppressed osteoblastic differentiation through Ror2/JNK (显示 MAPK8 蛋白) signaling in periodontal ligament stem cell-like cells.
Data show that receptor tyrosine kinase-like orphan receptor 2 (ROR2) is epigenetically silenced by promoter hypermethylation in colorectal cancer cell lines and in early stages of colorectal neoplasia tissue.
WNT5A (显示 WNT5A 蛋白) and ROR2 are induced by inflammatory mediators through NF-kB and STAT3 (显示 STAT3 蛋白) transcription factors, and are involved in the migration of human ovarian cancer cell line SKOV-3.
On these bases, we identified that miR (显示 MLXIP 蛋白)-208b targets receptor tyrosine kinase-like orphan receptor 2 gene by which miR (显示 MLXIP 蛋白)-208b can regulate the development of osteosarcoma.
Our findings suggest that receptor tyrosine kinase-like orphan receptor 2 may be an important regulator of epithelial-mesenchymal transition, primarily regulated the non-canonical Wnt (显示 WNT2 蛋白) signaling pathway in ovarian cancer cells, and may display a promising therapeutic target for ovarian cancer.
Knockdown of Ror2 expression in renal cell carcinoma (显示 MOK 蛋白) cells significantly reduced cell proliferation and induced apoptosis.
found no association between ROR2 staining and poor patient survival
The Ror2-mediated signaling might be activated in response to tissue damage and associated with progression of fibrosis in the submandibular gland (SMG (显示 SNRPG 蛋白)).
Ror2 plays a critical role in regulating the cell cycle progression of reactive astrocytes following brain injury
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2, which influenced Ras Homology Family Member A (显示 CXCL14 蛋白) (RhoA (显示 RHOA 蛋白)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1 (显示 ROCK1 蛋白)) activity downstream of Dishevelled-2 (Dvl2 (显示 DVL2 蛋白)).
Here, the study of two Ror2 mutants connects aberrant germ cell migration to defects in meiosis and supports the diffusion model of meiotic entry.
Although Ror1 (显示 ROR1 蛋白)-mutant mice show no apparent defects in ureteric bud (UB) formation, Ror1 (显示 ROR1 蛋白); Ror2-double-mutant mice exhibit either defects in UB outgrowth and branching morphogenesis, associated with the loss of the MM from the UB domain, or ectopic formation of the UB.
The Wnt5a (显示 WNT5A 蛋白)-Ror2 axis promotes the signaling circuit between interleukin-12 and interferon-gamma (显示 IFNG 蛋白) in colitis
Non-canonical Wnt5a (显示 WNT5A 蛋白)/Ror2 signaling regulates kidney morphogenesis by controlling intermediate mesoderm extension.
Ror2 plays an important role in mammary gland development in mice.
The activation of Wnt5a (显示 WNT5A 蛋白)-Ror2 signaling in epithelial cells undergoing epithelial-to-mesenchymal transition (EMT (显示 ITK 蛋白)) may play an important role in disrupting TBM via MMP-2 (显示 MMP2 蛋白) induction during renal fibrosis.
The results indicate an important role of Wnt5a (显示 WNT5A 蛋白)-Ror2 signaling in morphogenesis of the metanephric mesenchyme to ensure proper epithelial tubular formation of the ureteric bud required for kidney development.
In the Xenopus embryo, Ptk7 (显示 PTK7 蛋白) functionally interacts with Ror2 to regulate protocadherin papc (显示 PCDH8 蛋白) expression and morphogenesis.
Xenopus adult stem cells originate from the larval absorptive cells expressing Ror2, which require Wnt5a (显示 WNT5A 蛋白)/Ror2 signaling for their dedifferentiation accompanied by changes in cell morphology.
Data show that PAPC (显示 PCDH8 蛋白) signaling via RhoA (显示 RHOA 蛋白) and Wnt5a (显示 WNT5A 蛋白)/Ror2 activity are required to keep cells aligned in apical-basal orientation during invagination of the ear placode.
Transcriptional regulation of XPAPC (显示 PCDH8 蛋白) by XWnt-5A (显示 WNT5A 蛋白) requires the receptor tyrosine kinase Ror2.
demonstrated that this anti-canonical Wnt (显示 WNT2 蛋白) activity of Del1 is dependent on the Ror2 pathway, which is activated by the non-canonical Wnt (显示 WNT2 蛋白) ligands
The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.
neurotrophic tyrosine kinase receptor-related 2
, tyrosine-protein kinase transmembrane receptor ROR2
, neurotrophic tyrosine kinase, receptor related 2
, neurotrophic tyrosine kinase, receptor-related 2
, receptor tyrosine kinase-like orphan receptor 2
, tyrosine-protein kinase transmembrane receptor ROR2-like
, LOW QUALITY PROTEIN: tyrosine-protein kinase transmembrane receptor ROR2
, receptor tyrosine kinase Xror2
, receptor tyrosine kinase like orphan receptor 2 L homeolog
, receptor tyrosine kinase-like orphan receptor 2 L homeolog