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Human MME Protein expressed in Wheat germ - ABIN1311049
Li, Tao, Bova, Liu, Chan, Zhu, Zhang: Detection and verification of glycosylation patterns of glycoproteins from clinical specimens using lectin microarrays and lectin-based immunosorbent assays. in Analytical chemistry 2011
Mouse (Murine) MME Protein expressed in Human Cells - ABIN2007528
Oefner, DArcy, Hennig, Winkler, Dale: Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon. in Journal of molecular biology 2000
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Human MME Protein expressed in HEK-293 Cells - ABIN2181505
Pardossi-Piquard, Dunys, Yu, St George-Hyslop, Alves da Costa, Checler: Neprilysin activity and expression are controlled by nicastrin. in Journal of neurochemistry 2006
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In this meta-analysis of the Han Chinese population, neprilysin confers genetic susceptibility to Alzheimer's disease in Han Chinese populations.
CD10 is a necessary component conferring the L1 effects in CRC (显示 CALR 蛋白) cells. The identification of gene expression patterns of L1-domain-specific point mutations may provide novel markers and targets for interfering with L1-mediated CRC (显示 CALR 蛋白) progression.
High CD10 expression is associated with lymphoma in Waldeyer ring.
Rare Variants in MME, Encoding Metalloprotease Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies
CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine
High CD10 expression is associated with Basal cell carcinoma of the skin.
the dynamic behavior of human NEP and NEP2 (显示 MMEL1 蛋白) proteins was monitored by conducting molecular dynamics (MD) simulations.
This study reveals some unusual findings in otherwise classical disease entity, like absence of palpable spleen, presence of lymphadenopathy, normal or elevated leukocyte counts, expression of CD10, which at times could be diagnostically challenging.
Case Report: endometrial mixed carcinoma with the neuroendocrine component expressing CD10 that showed a long survival.
CD10 and Bcl2 (显示 BCL2 蛋白) expression in tumor cells could give convincing diagnostic value to distinguish squamous cell carcinoma from seborrheic keratosis
results indicate that NEP accelerates adipogenesis through enhancement of insulin (显示 INS 蛋白)-mediated PI3K-Akt (显示 AKT1 蛋白) activation and imply a high therapeutic value of NEP in treating obesity and obesity-related disorders.
Rare Variants in MME, Encoding Metalloprotease (显示 ADAMTS7 蛋白) Neprilysin, Are Linked to Late-Onset Autosomal-Dominant Axonal Polyneuropathies
Amyloid beta (Abeta (显示 APP 蛋白))-degrading effects of overexpressed neprilysin can block deleterious BACE1 (显示 BACE 蛋白)-elevating mechanisms that accelerate Abeta (显示 APP 蛋白) production
Serum CD10 levels might serve as a useful marker of synchronous and metachronous liver metastasis in colorectal cancer.
Cell hypoxia in neuroblastoma (显示 ARHGEF16 蛋白) cells results in up-regulation of neprilysin expression.
Neprilysin knockout mice developed more severe hyperalgesia than wild-type mice.
Data indicate that 5-aza-deoxycytidine induced the demethylation of neprilysin (NEP) gene and significantly increased NEP expression in a dose-dependent manner.
Data indicate an important, previously neglected, role of NEP for regulation of luminal factors in the epididymis and suggest a novel role for CNP (显示 CNP 蛋白)/guanylyl cyclase B in the epididymal epithelium.
exogenous neprilysin was localized mainly in endosomes, thereby effectively excluding Abeta (显示 APP 蛋白) oligomers from the brain. AAV vector-mediated gene transfer may provide a therapeutic strategy for neurodegenerative diseases
These data suggest that NEP plays an important role in regulating the hair cycle by its increased expression and activity in the follicular epithelium during early anagen.
Neutral endopeptidase 24.11 and DPP-IV (显示 DPP4 蛋白) is superior to DPP-IV (显示 DPP4 蛋白) inhibition alone in preserving intact GLP-1 (显示 GCG 蛋白), which implies possibility that the combination has therapeutic potential.
This study provides evidence that NEP 24.11 is an important mediator of the degradation of both endogenous and exogenous glucagon (显示 GCG 蛋白) in vivo.
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing.
, common acute lymphocytic leukemia antigen
, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)
, membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)
, membrane metallo-endopeptidase variant 1
, membrane metallo-endopeptidase variant 2
, neutral endopeptidase 24.11
, skin fibroblast elastase
, common acute lymphoblastic leukemia antigen
, neutral endopeptidase
, neprilysin-410 short isoform
, membrane metallo endopeptidase
, membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase)
, LOW QUALITY PROTEIN: neprilysin