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Mouse (Murine) KIT Ligand Protein expressed in Escherichia coli (E. coli) - ABIN413775
Fukuda, Bian, King, Pelus: The chemokine GRObeta mobilizes early hematopoietic stem cells characterized by enhanced homing and engraftment. in Blood 2007
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Human KIT Ligand Protein expressed in Escherichia coli (E. coli) - ABIN2018375
Lili, Chaozhan, Xindu: Expression, renaturation and simultaneous purification of recombinant human stem cell factor in Escherichia coli. in Biotechnology letters 2006
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Human KIT Ligand Protein expressed in Escherichia coli (E. coli) - ABIN413772
Kinzfogl, Hangoc, Broxmeyer: Neurexophilin 1 suppresses the proliferation of hematopoietic progenitor cells. in Blood 2011
Mouse (Murine) KIT Ligand Protein expressed in Escherichia coli (E. coli) - ABIN804039
Vas, Wandhoff, Dörr, Niebel, Geiger: Contribution of an aged microenvironment to aging-associated myeloproliferative disease. in PLoS ONE 2012
Authors show here that cyclin F (显示 CCNF 蛋白), a substrate receptor F-box protein for the SCF (Skp1 (显示 SKP1 蛋白)/Cul1 (显示 CUL1 蛋白)/F-box) family of E3 ubiquitin ligases, is a bona fide AKT (显示 AKT1 蛋白) substrate.
A statistically significant relationship was found between stem cell factor level and oocyte maturation, embryo quality, and clinical pregnancy.
PAR2 (显示 F2RL1 蛋白) plays a direct role in melanogenesis by increasing SCF secretion from keratinocytes.
We did not find any KITLG mutation in two affected individuals with familial progressive hyperpigmentation and hypopigmentation.
results suggest that SCF can accelerate cell homing and the maturation of the pulp-dentin complex in human immature teeth.
SCF is a critical regulatory factor for conceptus development and implantation during pregnancy in pigs.
the critical physiological role of the KIT-ET3 (显示 EDN3 蛋白)-NO pathway in fulfilling high demand (exceeding basal level) of endothelium-dependent NO generation for coping with atherosclerosis, pregnancy, and aging, is reported.
results revealed that the Th17-mediated inflammatory environment promotes mast cell accumulation through keratinocyte-derived SCF
Bone marrow adipocytes synthesize SCF, promoting hematopoietic stem cell proliferation/regeneration.
Hypoxia microenvironment in hepatocellular carcinoma up-regulates HIF2 (显示 EPAS1 蛋白)/SCF expression, which in turn promotes angiogenesis and HCC (显示 FAM126A 蛋白) metastasis.
The results of this study suggest that NAR (显示 CPSF4 蛋白) relieves Lop-induced constipation by increasing the levels of interstitial cells of Cajal markers (c-Kit and SCF), as well as AQP3 (显示 AQP3 蛋白). Thus, NAR (显示 CPSF4 蛋白) may be effective as a candidate in patients suffering from lifestyle-induced constipation.
persistent distention/stretch on colonic smooth muscle cells could suppress SCF production probably through Ca(2 (显示 CA2 蛋白)+) -ERK (显示 EPHB2 蛋白)-AP-1 (显示 JUN 蛋白)-miR (显示 MLXIP 蛋白)-34c deregulation.
Activation of c-kit signalling by SCF promotes migration of cardiac stem cells with increased phosphorylation of CXCR4 (显示 CXCR4 蛋白)-serine 339, p38 mitogen-activated protein kinase (p38 MAPK (显示 MAPK14 蛋白)) and extracellular regulated protein kinases 1/2 (ERK1/2).
These findings support the view that SCF, in addition to its pro-proliferative effects, is important for the differentiation of MCs (显示 SMCP 蛋白).
In vitro, SCF induced the phosphorylation of p38 MAPK (显示 MAPK14 蛋白) and cofilin (显示 CFL1 蛋白), leading to the migration of cardiac stem cells.
MAPK3 (显示 MAPK3 蛋白)/1 participates in primordial follicle activation through mTORC1-KITL signaling.
MicroRNA-205 maintains T cell development following stress by regulating Foxn1 (显示 FOXN2 蛋白) and its two regulated targets, stem cell factor and ccl25 (显示 CCL25 蛋白), following stress.
These findings indicate the SCF/Kit signaling insufficiency may contribute to the underdevelopment of ICCs and intestinal motility dysfunction upon hypoxia exposure.
SCF/c-kit signaling may potentiate chronic hypoxia-induced vascular remodeling by modulating ERK activation. Inhibition of c-kit activity may be a potential strategy to alleviate PH
Oocyte-derived signals interact locally to mediate granulosa and theca cell function. SCF has a role in modulating this local interaction.
little evidence was found for the KITLG gene being linked to variation in colour
FGF7 (显示 FGF7 蛋白) may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG signaling pathway.
chi-miR (显示 MYLIP 蛋白)-204-5p and chi-miR (显示 MYLIP 蛋白)-211 could change the expression levels of the KITLG gene and reduce granulosa cell proliferation.
Results suggest that the KITLG gene is a strong candidate gene affecting litter size in goats.
This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene.
, c-Kit ligand
, familial progressive hyperpigmentation 2
, kit ligand
, mast cell growth factor
, steel factor
, stem cell factor
, C-kit ligand
, Steel factor
, cloud gray
, hematopoietic growth factor KL
, steel factor/kit ligand
, stem cell factor KL-1
, KIT ligand precursor form 1
, KIT ligand precursor form 4
, c-kit ligand
, stem cell factor, CSF
, mast cell growth factor (white heifer disease)
, Mast cell growth factor
, stem cell factor homolog