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new basis of DDX23-Linc00630-HDAC1 (显示 HDAC1 抗体) signal axis for understanding its pathogenicity, which could be further developed as a valuable therapeutic strategy
pausing of RNA polymerase II (RNA Pol II (显示 0 抗体)) initiates a signaling cascade whereby the serine/arginine protein kinase 2 (显示 PKC 抗体) (SRPK2 (显示 SRPK2 抗体)) phosphorylates the DDX23 helicase, culminating in the suppression of R-loops.
SRPK2 (显示 SRPK2 抗体) knock down results in hypophosphorylation of the arginine-serine (RS) domain-containing human PRP28 protein (PRP28, also known as DDX23), and destabilizes PRP28 association with the tri (显示 VANGL2 抗体)-snRNP (显示 LSM2 抗体).
This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the U5 snRNP complex\; it may facilitate conformational changes in the spliceosome during nuclear pre-mRNA splicing. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined.
U5 snRNP 100 kD protein
, 100 kDa U5 snRNP-specific protein
, DEAD box protein 23
, PRP28 homolog, yeast
, PRP28p homolog
, probable ATP-dependent RNA helicase DDX23