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these results showed that the NTB-A (显示 SLAMF6 蛋白)/SAP (显示 APCS 蛋白) pathway regulates T-cell activation and restimulation-induced cell death during human tuberculosis
this paper shows that the X-linked lymphoproliferative disease gene product SAP (显示 APCS 蛋白) regulates signals induced through the co-receptor SLAM (显示 SLAMF1 蛋白)
we describe for the first time the clinical manifestations associated with XLP-1 based on the c.278G>A variant in the SH2D1A gene. The patient had a relatively late age of onset and presented mainly with primary HLH associated with EBV infection without a familial history of immunodeficiency.
this study shows reduced intracellular SAP (显示 APCS 蛋白) expression in iNKT cells and other lymphocytes in the blood from common variable immunodeficiency
in X-linked lymphoproliferative disease patient (显示 APCS 蛋白)s, SAP deficiency reduces CD74 expression, resulting in the perturbation of B cell maintenance from the naive stage
study concludes that systemic lupus erythematosus (SLE) T cells display reduced levels of the adaptor protein SAP (显示 APCS 蛋白), probably as a result of continuous T cell activation and degradation by caspase-3 (显示 CASP3 蛋白). Restoration of SAP (显示 APCS 蛋白) levels in SLE T cells corrects the overexcitable lupus T cell phenotype.
High LAT1 expression correlated with significantly shorter prostate specific antigen recurrence-free survival in patients receiving androgen deprivation therapy
We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (显示 SLAMF1 蛋白))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.
In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.
The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation
naive T cells regulate B cell survival in a SAP (显示 APCS 蛋白)-dependent manner
SAP (显示 APCS 蛋白)-dependent activating SFR signaling is essential for NKT (显示 CTSL1 蛋白) cell selection.
SAP (显示 APCS 蛋白) differentially regulates the late-stage lineage decisions of iNKT cell subsets. These results also provide evidence that iNKT1, iNKT2, and iNKT17 cells are differentially regulated by SAP (显示 APCS 蛋白). SAP (显示 APCS 蛋白)-dependent signals are essential for the fate decisions that drive the differentiation of iNKT2 but not iNKT1 and NKT17 cells.
SAP (显示 APCS 蛋白) is an essential molecule for autoimmune antibody production.
SLAM (显示 SLAMF1 蛋白)-SAP (显示 APCS 蛋白) signaling promotes differentiation of IL-17 (显示 IL17A 蛋白)-producing T cells and progression of experimental autoimmune encephalomyelitis.
these data suggest that SAP (显示 APCS 蛋白) is critical for regulating type II NKT (显示 CTSL1 蛋白) cell responses.
functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability
Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (显示 APCS 蛋白)-/- mice and in Rag-/- mice into which B cells derived from SAP (显示 APCS 蛋白)-/- mice together with wt CD4 (显示 CD4 蛋白)+ T cells had been transferred.
SAP (显示 APCS 蛋白) plays an essential role in CIA (显示 NCOA5 蛋白) because of Fyn (显示 FYN 蛋白)-independent and Fyn (显示 FYN 蛋白)-dependent effects on TFH cells and, possibly, other T cell types.
This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.
Duncan disease SH2-protein
, SH2 domain-containing protein 1A
, SLAM associated protein/SH2 domain protein 1A
, SLAM-associated protein
, T cell signal transduction molecule SAP
, T-cell signal transduction molecule SAP
, signaling lymphocyte activation molecule-associated protein
, signaling lymphocytic activation molecule-associated protein
, Duncan disease homolog
, SH2 domain protein 1A