SH2D1A Protein (His tag)
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- 抗原 See all SH2D1A 蛋白
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This SH2D1A protein is labelled with His tag.
- 原理
- Recombinant Human SH2D1A/SAP Protein (His Tag)(Active)
- 序列
- Pro 2-Lys 97
- 产品特性
- A DNA sequence encoding the human SH2D1A isoform 1 (NP_002342.1) (Pro 2-Lys 97) was expressed, with a polyhistidine tag at the N-terminus.
- 纯度
- > 94 % as determined by reducing SDS-PAGE.
- Biological Activity Comment
- 1. Measured by its ability to bind recombinant human SLAMF1 in a functional ELISA.2. Measured by its ability to bind recombinant human SLAMF6 in a functional ELISA.3. Measured by its ability to bind recombinant mouse SLAMF6 in a functional ELISA.4. Measured by its ability to bind recombinant mouse CD84 in a functional ELISA.
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- Discover our top product SH2D1A 蛋白
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SH2 Domain Containing 1A (SH2D1A) (AA 1-128) protein (His tag)
SH2D1A 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
SH2 Domain Containing 1A (SH2D1A) (AA 1-128) protein (GST tag)SH2D1A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
SH2 Domain Containing 1A (SH2D1A) (AA 1-126) protein (Strep Tag)Crystallography grade SH2D1A 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
SH2 Domain Containing 1A (SH2D1A) proteinSH2D1A 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
SH2 Domain Containing 1A (SH2D1A) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)SH2D1A 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.5, 20 % glycerol
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SH2D1A (SH2 Domain Containing 1A (SH2D1A))
- 别名
- SH2D1A/SAP (SH2D1A 产品)
- 别名
- DSHP Protein, EBVS Protein, IMD5 Protein, LYP Protein, MTCP1 Protein, SAP Protein, SAP/SH2D1A Protein, XLP Protein, XLPD Protein, RGD1562408 Protein, Gm686 Protein, SH2D1A Protein, SH2 domain containing 1A Protein, SH2D1A Protein, Sh2d1a Protein
- 背景
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Background: SH2 domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2 domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cells. SH2D1A (SAP) interacts via its SH2 domain with a motif (TIYXXV) present in the cytoplasmic tail of the cell-surface receptors, including CD150 / SLAM, CD84, CD229 / Ly-9, and CD244 / 2B4. SH2D1A was expressed in EBV-carrying, tumor phenotype representative (type I), but not in EBV-carrying lymphoblastoid cell line (LCL)-like (type III) or EBV-negative Burkitt lymphoma (BL) lines. It has been supposed to be related to the X-linked lymphoproliferative disease which is also known as Duncan's disease or Purtilo syndrome.
Synonym: SH2 Domain-Containing Protein 1A; Duncan Disease SH2-Protein; Signaling Lymphocytic Activation Molecule-Associated Protein; SLAM-Associated Protein; T-Cell Signal Transduction Molecule SAP; SH2D1A;DSHP;EBVS;IMD5;LYP;MTCP1;SAP/SH2D1A;XLP;XLPD;XLPD1
- 分子量
- 15.6 kDa
- NCBI登录号
- NP_002342
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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