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Human Monoclonal HLAC Primary Antibody for CyTOF, FACS - ABIN4220954
Apps, Qi, Carlson, Chen, Gao, Thomas, Yuki, Del Prete, Goulder, Brumme, Brumme, John, Mallal, Nelson, Bosch, Heckerman, Stein, Soderberg, Moody, Denny, Zeng, Fang, Moffett, Lifson, Goedert et al.: Influence of HLA-C expression level on HIV control. ... in Science (New York, N.Y.) 2013
Show all 3 Pubmed References
In this study, we describe and confirm the distinct expression of HLA-F, HLA-G, HLA-E, and HLA-C in placental tissue
childhood acute lymphoblastic leukaemic patients but not healthy controls exhibited B cell populations with very low HLA-C and -E expression levels that could be consistently allocated to the CD19 (显示 CD19 抗体)+CD45 (显示 PTPRC 抗体)- leukaemic subset
propose that HIV-1 infectivity might depend both on the amounts of HLA-C molecules and on their stability as trimeric complex. According to this model, individuals with low-expression HLA-C alleles and unstable binding to beta2m/peptide might have worse control of HIV-1 infection and an intrinsically higher capacity to support viral replication
KIR2DL2/HLA-C( *)12:02 and KIR2DL2/HLA-C( *)14:03 compound genotypes have protective effects on control of HIV-1.
Data establish the C2 allele as a novel genetic risk factor associated with congenital heart block. This observation supports a model in which fetuses with C2 ligand expression and maternal anti-SSA/Ro (显示 TROVE2 抗体) positivity may have impaired NK cell surveillance, resulting in unchecked cardiac inflammation and scarring.
results provide the structural basis for understanding peptide repertoire selection in HLA-C*06:02.
Single-nucleotide polymorphisms FOXF1 rs9936833 and MHC rs9257809 remained significantly associated with presence of gastroesophageal acid reflux. The association for risk allele C in FOXF1 rs9936833 and risk allele A in MHC rs9257809 with the presence of acid reflux suggests a potential pathophysiologic mechanism for the role of genetic influences in Barret Esophagus development.
The minor alleles of rs2395029, rs9264942, and rs3689068 in the HCP5 and HLA-C, and ZNRD1 (显示 ZNRD1 抗体) genes associate with lower viral loads (VL) among antiretroviral-naive individuals and with shorter time to first VL less 51 copies/ml during anti-HIV therapy.
HLA-C*04:01 predisposes to nevirapine-induced Stevens-Johnson syndrome/toxic epidermal necrolysis in , but not to other hypersensitivity phenotypes in a sub-Saharan African HIV-infected population
The HLA-B*42, HLA-C*17, HLA-DPA1*03, and HLA-DPB1*105 genotypes were associated with allergic asthma and the HLA-B*48 genotype with the nonallergic phenotype.
HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described
HLA class I histocompatibility antigen, C alpha chain
, HLA class I histocompatibility antigen, Cw-1 alpha chain
, MHC class I antigen heavy chain HLA-C
, human leukocyte antigen-C alpha chain
, major histocompatibility antigen HLA-C