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CLF-1 (显示 CRLF1 蛋白), based on its binding site for CLC (显示 CLC 蛋白) and on two additional and independent sites for CNTFRalpha (显示 CNTFR 蛋白) and sorLA (显示 SORL1 蛋白), is a key player in CLC (显示 CLC 蛋白) and CNTFRalpha (显示 CNTFR 蛋白) signaling and turnover.
Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP (显示 CTF2 蛋白)) signalling and their roles in development, adulthood, cancer and degenerative disorders.
albuminuria in focal segmental glomerulosclerosis is related to qualitative or quantitative changes in the CLCF1-CRLF1 (显示 CRLF1 蛋白) complex.
activation of the Jak (显示 JAK3 蛋白)-STAT (显示 STAT1 蛋白) cascade is essential for corticotroph NNT-1/BSF-3 signaling.
Structural and docking interaction studies showed that the R197L substitution destabilized the contact site between CLC (显示 CLC 蛋白) and CNTFRalpha (显示 CNTFR 蛋白).
Ciliary neurotrophic factor (显示 CNTF 蛋白), cardiotrophin-like cytokine, and neuropoietin (显示 CTF2 蛋白) share a conserved binding site on the ciliary neurotrophic factor receptor alpha (显示 CNTFR 蛋白) chain (显示 FCGRT 蛋白)
CLC (显示 CLC 蛋白) plays a role in astrocyte differentiation via STAT3 (显示 STAT3 蛋白) activation within the developing brain
neurotrophin-1/B-cell stimulating factor 3(NNT-1/BSF-3) is expressed in pituitary folliculostellate TtT/GF cells and induced by PKC-, PKA-, and ERK1/2-dependent mechanisms
IL-6 (显示 IL6 蛋白) (gp130 (显示 LRPPRC 蛋白)) family cytokine members include CLC/NNT1/BSF3 and IL-27 (显示 IL27 蛋白) [review]
In this study, Clc (显示 CLC 蛋白) knockout mice had decreased facial motility, did not suckle, died within 24 hours, and had 32% and 29% fewer motor neurons in the facial nucleus and lumbar ventral horn, respectively.
This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
cardiotrophin-like cytokine factor 1
, B-cell stimulating factor 3
, B-cell stimulatory factor 3
, B-cell-stimulating factor 3
, CRLF1 associated cytokine-like factor 1
, neurotrophin-1/B-cell stimulating factor-3
, novel neurotrophin-1
, b cell-stimulating factor 3
, cardiotrophin-like cytokine