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RAG2 产品

(Recombination Activating Gene 2 (RAG2))

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This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms. [provided by RefSeq, Jul 2008].

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Featured RAG2 Categories

RAG2 抗体

High quality antibodies with extensive validation data.

RAG2 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

RAG2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended RAG2 抗体

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Application WB, IF, IHC (p), ICC
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Cat. No. ABIN2856698
Quantity 100 μL
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Cat. No. ABIN950151
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Application WB, ELISA
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Cat. No. ABIN519621
Quantity 100 μg
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Recommended RAG2 ELISA试剂盒

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Reactivity
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Reactivity Human
Analytical Method Quantitative Sandwich ELISA
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Cat. No. ABIN6969857
Quantity 96 tests
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Analytical Method
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Cat. No. ABIN1166582
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Cat. No. ABIN995325
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Recommended RAG2 蛋白

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Source Wheat germ
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Quantity 2 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
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Cat. No. ABIN3094940
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Reactivity Mouse
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Cat. No. ABIN3133308
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Latest Publications for our RAG2 Products

Nagawa, Hirose, Nishizumi, Nishihara, Sakano: "Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 38360-8, (2004) (PubMed).

Synonyms and alternative names related to RAG2

recombination activating 2 (RAG2), recombination activating gene 2 (RAG2), recombination activating gene 2 (Rag2), recombination activating 2 (Rag2), recombination activating gene 2 (rag2), recombination activating gene 2 S homeolog (rag2.S), RAG-2, Rag-2, rag-2, zgc:136743

Protein level used designations for RAG2

  • recombination activating gene 2
  • recombination activating protein 2
  • V(D)J recombination-activating protein 2-like
  • V(D)J recombination-activating protein 2
  • recombinase activating gene 2
  • v(D)J recombination-activating protein 2
  • RAG-2
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