RAD51C 产品
(DNA Repair Protein RAD51 Homolog 3 (RAD51C))
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This gene is a member of the RAD51 family of related genes, which encode strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. This gene product interacts with two other DNA repair proteins, encoded by RAD51B and XRCC3, but not with itself. The protein copurifies with XRCC3 protein in a complex, reflecting their endogenous association and suggesting a cooperative role during recombinational repair. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing has been observed for this gene and two variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
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Featured RAD51C Categories
Recommended RAD51C 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, RNAi
Validations
- (7)
Cat. No.
ABIN562569
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
IHC
Validations
- (3)
Cat. No.
ABIN7262879
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (3)
Cat. No.
ABIN6259171
Quantity
100 μL
Datasheet
Datasheet
Recommended RAD51C 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1317285
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3094865
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3136898
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our RAD51C Products
: "BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability." in: Nature communications, Vol. 8, Issue 1, pp. 1470, (2017) (PubMed).: "Olaquindox disrupts tight junction integrity and cytoskeleton architecture in mouse Sertoli cells." in: Oncotarget, Vol. 8, Issue 51, pp. 88630-88644, (2017) (PubMed).
: "Characterisation of the novel deleterious RAD51C p.Arg312Trp variant and prioritisation criteria for functional analysis of RAD51C missense changes." in: British journal of cancer, Vol. 117, Issue 7, pp. 1048-1062, (2017) (PubMed).
: "Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair." in: Oncogene, Vol. 33, Issue 40, pp. 4803-12, (2014) (PubMed).
: "RAD51C-deficient cancer cells are highly sensitive to the PARP inhibitor olaparib." in: Molecular cancer therapeutics, Vol. 12, Issue 6, pp. 865-77, (2013) (PubMed).
: "BRCA2 is epistatic to the RAD51 paralogs in response to DNA damage." in: DNA repair, Vol. 12, Issue 4, pp. 306-11, (2013) (PubMed).
: "Systematic screen identifies miRNAs that target RAD51 and RAD51D to enhance chemosensitivity." in: Molecular cancer research : MCR, Vol. 11, Issue 12, pp. 1564-73, (2013) (PubMed).
: "Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 29, pp. 11800-5, (2012) (PubMed).
: "MiR-96 downregulates REV1 and RAD51 to promote cellular sensitivity to cisplatin and PARP inhibition." in: Cancer research, Vol. 72, Issue 16, pp. 4037-46, (2012) (PubMed).
: "Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway." in: Molecular and cellular biology, Vol. 33, Issue 2, pp. 387-95, (2012) (PubMed).
Synonyms and alternative names related to RAD51C
RAD51 paralog C (RAD51C), RAD51 paralog C (Rad51c), Rad51 recombinase D (Rad51D), RAD51 paralog C (rad51c), Rad51 DNA recombinase 3 (RAD51C), RAD51C protein (RAD51C), RAD51 homolog C (Rad51c), RAS associated with diabetes protein 51C (RAD51C), ATRAD51C, BROVCA3, CG2412, Dm CG2412, Dmel\\CG2412, F4L23.21, FANCO, R51H3, RAD51C, Rad51c, Rad51l2, RAD51L2, RAS associated with diabetes protein 51C, RGD1563765, zgc:101596Protein level used designations for RAD51C
- Rad51 homolog c
- RAD51 homolog C
- CG2412-PB
- Rad51C-PB
- RAD51 homolog C (S. cerevisiae)
- DNA repair protein RAD51 homolog 3
- Rad51 DNA recombinase 3
- RAD51C protein
- RAD51-like protein 2
- yeast RAD51 homolog 3
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