PTK2B 抗体
(PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
recommended
PTK2B 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
recommended
recommended
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Popular PTK2B 抗体
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Reactivity
Application
Validations
Cat. No.
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Datasheet
Reactivity
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Validations
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Cat. No.
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Quantity
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Datasheet
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Reactivity
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Application
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Cat. No.
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Quantity
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Quantity
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Datasheet
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Application
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Cat. No.
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Quantity
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Datasheet
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Cat. No.
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Quantity
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Application
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Quantity
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Cat. No.
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Quantity
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Datasheet
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Quantity
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Quantity
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Datasheet
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Application
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Quantity
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Datasheet
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Quantity
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Datasheet
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Latest Publications for our PTK2B 抗体
: "Chemotherapy-Induced Ca(2+) Release Stimulates Breast Cancer Stem Cell Enrichment." in: Cell reports, Vol. 18, Issue 8, pp. 1946-1957, (2017) (PubMed).: "Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis." in: Bone, Vol. 74C, pp. 58-68, (2015) (PubMed).
: "Down-regulation of miR-517a and miR-517c promotes proliferation of hepatocellular carcinoma cells via targeting Pyk2." in: Cancer letters, Vol. 329, Issue 2, pp. 164-73, (2013) (PubMed).
: "Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ..." in: The Journal of biological chemistry, Vol. 287, Issue 22, pp. 17963-74, (2012) (PubMed).
: "The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 8, pp. 5636-44, (2008) (PubMed).
: "Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons." in: Journal of cell science, Vol. 120, Issue Pt 17, pp. 3034-44, (2007) (PubMed).
: "Focal adhesion kinase is critical for entry of Kaposi's sarcoma-associated herpesvirus into target cells." in: Journal of virology, Vol. 80, Issue 3, pp. 1167-80, (2006) (PubMed).
: "The calcium-dependent activity of large-conductance, calcium-activated K+ channels is enhanced by Pyk2- and Hck-induced tyrosine phosphorylation." in: American journal of physiology. Cell physiology, Vol. 287, Issue 3, pp. C698-706, (2004) (PubMed).
: "Acid sensing in renal epithelial cells." in: The Journal of clinical investigation, Vol. 114, Issue 12, pp. 1696-9, (2004) (PubMed).
"Fresh concepts in dental design." in: Journal of the California Dental Association, Vol. 32, Issue 5, pp. 365-6, (2004) (PubMed).
Aliases for PTK2B 抗体
protein tyrosine kinase 2 beta (PTK2B) 抗体PTK2 protein tyrosine kinase 2 beta (Ptk2b) 抗体
protein tyrosine kinase 2 beta (Ptk2b) 抗体
protein tyrosine kinase 2aa (ptk2aa) 抗体
CADTK 抗体
CAKB 抗体
CAKbeta 抗体
E430023O05Rik 抗体
FADK2 抗体
fak1b 抗体
FAK2 抗体
PKB 抗体
PTK 抗体
ptk2.2 抗体
ptk2b 抗体
PYK2 抗体
Pyk2 抗体
RAFTK 抗体
Raftk 抗体
si:ch1073-355e8.1 抗体
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