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- 抗原 See all PTK2B 抗体
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
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抗原表位
- Tyr579
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTK2B antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人, 小鼠
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized non-phosphopeptide derived from Human PYK2 around the phosphorylation site of tyrosine 579 (E-D-Y(p)-Y-K).
- 亚型
- IgG
- Top Product
- Discover our top product PTK2B Primary Antibody
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anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibody
PTK2B 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 1-1009) antibodyPTK2B 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 682-871) antibodyPTK2B 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1F9 unconjugated
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (pTyr402) antibodyPTK2B 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 805-838), (C-Term) antibodyPTK2B 适用: 人 WB, IHC (p), IF 宿主: 兔 Polyclonal RB50594 unconjugated
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) antibodyPTK2B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 682-871) antibodyPTK2B 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal X1 unconjugated
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 812-861) antibodyPTK2B 适用: 人, 小鼠, 大鼠, 犬, 兔, Pig, 马, 猴, 豚鼠, Cow, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 815-997) antibodyPTK2B 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 5E2D5 unconjugated
anti-PTK2B Protein tyrosine Kinase 2 beta (PTK2B) (AA 707-875) antibodyPTK2B 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB:1:500-1:3000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PTK2B (PTK2B Protein tyrosine Kinase 2 beta (PTK2B))
- 别名
- PTK2B (PTK2B 产品)
- 别名
- CADTK antibody, CAKB antibody, FADK2 antibody, FAK2 antibody, PKB antibody, PTK antibody, PYK2 antibody, RAFTK antibody, CAKbeta antibody, E430023O05Rik antibody, Raftk antibody, Pyk2 antibody, fak1b antibody, ptk2.2 antibody, ptk2b antibody, si:ch1073-355e8.1 antibody, protein tyrosine kinase 2 beta antibody, PTK2 protein tyrosine kinase 2 beta antibody, protein tyrosine kinase 2aa antibody, PTK2B antibody, Ptk2b antibody, ptk2aa antibody
- 背景
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Background: Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption, this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation, this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca2+ levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC, this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN, this requires both SRC and PTK2/PYK2.
Lev S., Nature 376:737-745(1995).
Herzog H., Genomics 32:484-486(1996).
Sasaki H., J. Biol. Chem. 270:21206-21219(1995).
Aliases: CADTK antibody, CAK-beta antibody, CAKB antibody, CAKbeta antibody, Calcium regulated non receptor proline rich tyrosine kinase antibody, Calcium-dependent tyrosine kinase antibody, Cell adhesion kinase beta antibody, E430023O05Rik antibody, EC 2.7.10.2 antibody, FADK 2 antibody, FADK2 antibody, FAK2 antibody, FAK2_HUMAN antibody, Focal adhesion kinase 2 antibody, MGC124628 antibody, PKB antibody, Proline-rich tyrosine kinase 2 antibody, Protein kinase B antibody, Protein Tyrosine Kinase 2 Beta antibody, Protein-tyrosine kinase 2-beta antibody, PTK antibody, PTK2B antibody, PTK2B protein tyrosine kinase 2 beta antibody, PYK2 antibody, RAFTK antibody, RAFTK2 antibody, Related adhesion focal tyrosine kinase antibody
- UniProt
- Q14289
- 途径
- EGFR Signaling Pathway, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Cellular Glucan Metabolic Process, Cell-Cell Junction Organization, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, Positive Regulation of fat Cell Differentiation, VEGF Signaling
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