Phosphatase and Tensin Homolog 产品
(Phosphatase and Tensin Homolog (PTEN))
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This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\\/PKB signaling pathway. [provided by RefSeq, Jul 2008].
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Phosphatase and Tensin Homolog 抗体
High quality antibodies with extensive validation data.
Recommended Phosphatase and Tensin Homolog 抗体
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Reactivity
Application
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Cat. No.
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Datasheet
Reactivity
Human
Application
WB, IF, IHC (p)
Validations
- (2)
- (4)
Cat. No.
ABIN6242545
Quantity
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Datasheet
Datasheet
Reactivity
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Application
WB, ELISA, IHC, IF
Validations
- (7)
Cat. No.
ABIN3032214
Quantity
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Datasheet
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Reactivity
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Cat. No.
ABIN7437623
Quantity
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Datasheet
Datasheet
Recommended Phosphatase and Tensin Homolog 蛋白
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Source
Escherichia coli (E. coli)
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Cat. No.
ABIN7286591
Quantity
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Datasheet
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Reactivity
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Source
Escherichia coli (E. coli)
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ABIN7319750
Quantity
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Datasheet
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Reactivity
Rat
Source
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Validations
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Quantity
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Datasheet
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Latest Publications for our Phosphatase and Tensin Homolog Products
: "MiR221 promotes precursor B-cell retention in the bone marrow by amplifying the PI3K-signaling pathway in mice." in: European journal of immunology, Vol. 48, Issue 6, pp. 975-989, (2019) (PubMed).: "Gene expression profiles between cystic and solid vestibular schwannoma indicate susceptible molecules and pathways in the cystic formation of vestibular schwannoma." in: Functional & integrative genomics, Vol. 19, Issue 4, pp. 673-684, (2019) (PubMed).
: "TGF-β induces phosphorylation of phosphatase and tensin homolog: implications for fibrosis of the trabecular meshwork tissue in glaucoma." in: Scientific reports, Vol. 7, Issue 1, pp. 812, (2018) (PubMed).
: "Inhibitors of PARP-1 exert inhibitory effects on the biological characteristics of hepatocellular carcinoma cells in vitro." in: Molecular medicine reports, Vol. 16, Issue 1, pp. 208-214, (2018) (PubMed).
: "Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway." in: Frontiers in cellular neuroscience, Vol. 11, pp. 425, (2018) (PubMed).
: "Bone marrow mesenchymal stem cell-derived exosomal miR-21 protects C-kit+ cardiac stem cells from oxidative injury through the PTEN/PI3K/Akt axis." in: PLoS ONE, Vol. 13, Issue 2, pp. e0191616, (2018) (PubMed).
: "Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and ameliorates IL-21 mediated ..." in: Cytokine, Vol. 106, pp. 54-66, (2018) (PubMed).
: "Associations of Functional MicroRNA Binding Site Polymorphisms in IL23/Th17 Inflammatory Pathway Genes with Gastric Cancer Risk." in: Mediators of inflammation, Vol. 2017, pp. 6974696, (2018) (PubMed).
: "VprBP (DCAF1) Regulates RAG1 Expression Independently of Dicer by Mediating RAG1 Degradation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 201, Issue 3, pp. 930-939, (2018) (PubMed).
: "Changes in expression of special AT-rich sequence binding protein 1 and phosphatase and tensin homologue in kidneys of diabetic rats during ageing." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 33, Issue 10, pp. 1734-1741, (2018) (PubMed).
Synonyms and alternative names related to Phosphatase and Tensin Homolog
phosphatase and tensin homolog (PTEN), phosphatase and tensin homolog (Pten), phosphatase and tensin homolog L homeolog (pten.L), phosphatase and tensin homolog A (ptena), phosphatase and tensin homolog B (ptenb), 10q23del, 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, BZS, CWS1, DEC, fa11a08, fb73f10, fc83f12, fd16b10, fk90e11, GLM2, MHAM, Mmac, MMAC1, pten, PTEN1, PTENP1, si:bz1g13.4, TEP1, wu:fa11a08, wu:fb73f10, wu:fc52g04, wu:fc83f12, wu:fd16b10, wu:fk90e11, zgc:73086Protein level used designations for Phosphatase and Tensin Homolog
- MMAC1 phosphatase and tensin homolog deleted on chromosome 10
- mutated in multiple advanced cancers 1
- phosphatase and tensin-like protein
- phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
- protein tyrosine phosphatase and tensin-like protein
- phosphatase and tensin homolog deleted on chromosome ten
- protein/lipid phosphatase Pten
- homolog of human mutated in multiple advanced cancers
- phosphatase and tensin homolog (mutated in multiple advanced cancers 1)
- phosphatase and tensin homolog A
- phosphatase and tensin-like protein A
- phosphatase and tensin homolog B (mutated in multiple advanced cancers 1)
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