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PHKA1 产品

(phosphorylase Kinase, alpha 1 (Muscle) (PHKA1))
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010].

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Featured PHKA1 Categories

PHKA1 抗体

High quality antibodies with extensive validation data.

PHKA1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

PHKA1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended PHKA1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IHC (p), ICC
Validations
  • (4)
Cat. No. ABIN2856675
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN562210
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
Cat. No. ABIN7163404
Quantity 100 μg
Datasheet Datasheet

Recommended PHKA1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1148076
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1148078
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1148075
Quantity 96 tests
Datasheet Datasheet

Recommended PHKA1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1314914
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093469
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3133202
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our PHKA1 Products

Benzina, Pitaval, Lemercier, Lustremant, Frouin, Wu, Papine, Soussaline, Romeo, Gidrol: "A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation." in: Cellular and molecular life sciences : CMLS, (2015) (PubMed).

Quinlan, Seto, Turner, Vandebrouck, Floetenmeyer, Macarthur, Raftery, Lek, Yang, Parton, Cooney, North: "Alpha-actinin-3 deficiency results in reduced glycogen phosphorylase activity and altered calcium handling in skeletal muscle." in: Human molecular genetics, Vol. 19, Issue 7, pp. 1335-46, (2010) (PubMed).

Synonyms and alternative names related to PHKA1

phosphorylase kinase regulatory subunit alpha 1 (PHKA1), phosphorylase kinase, alpha 1a (muscle) (phka1a), phosphorylase kinase, alpha 1 (muscle) (phka1), phosphorylase kinase alpha 1 (Phka1), phosphorylase kinase regulatory subunit alpha 1 (Phka1), phosphorylase kinase, alpha 1 (muscle) (PHKA1), 5330411D17, 9830108K24Rik, Pcyt1b, Phka, PHKA, PHKA1, wu:fl37h01

Protein level used designations for PHKA1

  • phosphorylase kinase, alpha 1 (muscle)
  • phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform
  • phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform-like
  • phosphorylase kinase alpha M subunit
  • Phosphorylase kinase alpha M subunit
  • PhK-alpha-subunit
  • phosphorylase B kinase alpha subunit
  • phosphorylase kinase alpha-subunit
  • phosphorylase b kinase regulatory subunit alpha skeletal muscle isoform
  • phosphorylase kinase, alpha 1 (muscle), muscle glycogenosis
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