PSMC5 产品
(Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 5 (PSMC5))
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The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].
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Featured PSMC5 Categories
Recommended PSMC5 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF, ICC, IHC (p)
Validations
- (5)
Cat. No.
ABIN2856087
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC, IP
Validations
- (4)
Cat. No.
ABIN2780449
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
Cat. No.
ABIN7142238
Quantity
100 μg
Datasheet
Datasheet
Recommended PSMC5 蛋白
Latest Publications for our PSMC5 Products
: "Human Telomerase Reverse Transcriptase (hTERT) Positively Regulates 26S Proteasome Activity." in: Journal of cellular physiology, (2016) (PubMed).: "Nonproteolytic roles of 19S ATPases in transcription of CIITApIV genes." in: PLoS ONE, Vol. 9, Issue 3, pp. e91200, (2014) (PubMed).
: "Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor." in: The Biochemical journal, Vol. 458, Issue 1, pp. 95-107, (2014) (PubMed).
: "The 26S proteasome drives trinucleotide repeat expansions." in: Nucleic acids research, Vol. 41, Issue 12, pp. 6098-108, (2013) (PubMed).
: "The 19S proteasome positively regulates histone methylation at cytokine inducible genes." in: Biochimica et biophysica acta, Vol. 1789, Issue 11-12, pp. 691-701, (2009) (PubMed).
: "Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1." in: Molecular and cellular biology, Vol. 28, Issue 19, pp. 5837-50, (2008) (PubMed).
Synonyms and alternative names related to PSMC5
protease (prosome, macropain) 26S subunit, ATPase 5 (Psmc5), proteasome 26S subunit, ATPase 5 (PSMC5), proteasome 26S subunit, ATPase 5 (psmc5), proteasome 26S subunit, ATPase 5 L homeolog (psmc5.L), proteasome 26S subunit, ATPase 5 (Psmc5), proteasome 26S subunit, ATPase 5 S homeolog (psmc5.S), mSUG1, p45, p45/SUG, PSMC5, S8, SUG-1, sug-1, SUG1, sug1, Sug1, TBP10, tbp10, TRIP1, wu:fa14g03, wu:fb23a11, xsug1, zgc:92464Protein level used designations for PSMC5
- 26S protease regulatory subunit 8
- 26S proteasome AAA-ATPase subunit RPT6
- p45/SUG
- proteasome 26S subunit ATPase 5
- proteasome subunit p45
- MSUG1 protein
- Tat-binding protein homolog 10
- proteasome 26S ATPase subunit 5
- thyroid hormone receptor-interacting protein 1
- thyroid receptor interactor 1
- TRIP1
- for proteasomal ATPase (SUG1)
- peptidase (prosome, macropain) 26S subunit, ATPase 5
- protease (prosome, macropain) 26S subunit, ATPase 5
- proteasomal ATPase (SUG1)
- proteasome p45/SUG
- 26S protease subunit
- TAT-binding protein homolog 10
- SUG1 homolog
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