Purified recombinant Human IL12 protein Expression System: CHO cells Bioactivity: The ED50 was determined by the induction of IFN-gamma from NK cells co-stimulated with IL-18 is ? 1.0 ng/mL, corresponding to a specific activity of ? 1 x 10^6 units/mg.
IL12 is a potent regulator of cell mediated immune responses and it induces IFN-gamma production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue type mast cells. Among its biological activities IL12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells and induces the development of IFN-gamma producing Th1 cells. Alternative Names: NKSF protein, IL-12, Cytotoxic lymphocyte maturation factor protein, IL-12 protein, TSF protein, IL 12, CLMF protein, Interleukin 12 protein, IL 12 protein, CTL maturation factor protein, TCMF protein, IL-12 protein, IL12