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IL12 Protein (AA 23-215, AA 23-335)

This Recombinant IL12 protein is expressed in HEK-293 Cells.

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产品编号 ABIN7320573

发货至: 中国

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Quick Overview for IL12 Protein (AA 23-215, AA 23-335) (ABIN7320573)

抗原

See all IL12 蛋白

IL12 (Interleukin 12 (IL12))

蛋白类型

Recombinant

宿主

小鼠

资源

HEK-293 Cells

纯度

> 95 % as determined by reducing SDS-PAGE.

Discover our top product IL12 蛋白

产品特性

AA 23-215, AA 23-335

原理

Recombinant Mouse Interleukin-12/IL-12 Protein

序列

Met23-Ser335&Arg23-Ala215

产品特性

Recombinant Mouse Interleukin-12 is produced by our Mammalian expression system and the target gene encoding Met23-Ser335&Arg23-Ala215 is expressed.

过滤

0.2 μm filtered

内毒素水平

< 0.01 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment

Not validated for activity
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Interleukin 12 (IL12) (AA 23-328) (Active) protein (His-Avi Tag)
IL12 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active

Interleukin 12 (IL12) (AA 23-328) (Active) protein (Biotin,His-Avi Tag)
IL12 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active

Interleukin 12 (IL12) (AA 23-219), (AA 23-328) (Active) protein
IL12 宿主: 人宿主: HEK-293T Cells Recombinant > 95 % as analyzed by SDS-PAGE and HPLC. Active

Interleukin 12 (IL12) (AA 23-328) (Active) protein (His tag,DYKDDDDK Tag)
IL12 宿主: 人宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active

Interleukin 12 (IL12) (AA 23-328) (Active) protein (His tag,AVI tag,DYKDDDDK Tag,Biotin)
IL12 宿主: 人宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active

Interleukin 12 (IL12) protein
IL12 宿主: 人宿主: HEK-293 Cells Recombinant Greater than 95 % as determined by reducing SDS-PAGE. AM, ADA, IA, ScA

Interleukin 12 (IL12) (AA 23-219) protein (His tag,Fc Tag)
IL12 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. AM, ADA, IA, ScA

Interleukin 12 (IL12) (AA 23-328) (Active) protein (His tag)
IL12 宿主: 人宿主: Baculovirus infected Insect Cells Recombinant > 90 % SDS, AcA Active

Interleukin 12 (IL12) (AA 23-219) protein (His tag)
IL12 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by reducing SDS-PAGE.

Interleukin 12 (IL12) protein
IL12 宿主: 小鼠宿主: 大肠杆菌（E. Coli） Recombinant 95,00% SDS

限制

仅限研究用
状态

Lyophilized

缓冲液

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

储存条件

4 °C,-20 °C,-80 °C

储存方法

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

有效期

12 months
抗原

IL12 (Interleukin 12 (IL12))

别名

Interleukin-12/IL-12

背景

CLMF p35,CLMF p40,Cytotoxic lymphocyte maturation factor 35 kDa subunit,Cytotoxic lymphocyte maturation factor 40 kDa subunit,IL-12,IL-12 subunit p35,IL-12 subunit p40,IL-12A,IL-12B,Interleukin 12,Interleukin-12 subunit alpha,Interleukin-12 subunit beta,Mouse IL-12 is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. Human and mouse IL-12 share 70 % and 60 % amino acid sequence identity in their p40 and p35 subunits, respectively. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on murine cells. It is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) from T cells and natural killer (NK) cells, and reduces IL-4 mediated suppression of IFN-γ. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes.

分子量

Calculated MW: 35.8&21.7 kDa
Observed MW: 40-55&20-28 kDa

UniProt

P43432, P43431

途径

JAK/STAT Signaling, TLR signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome