Hypoxia-inducible factor 1, alpha subunit inhibitor (HIF1AN), a member of the Fe2+ and 2-oxoglutarate-dependent dioxygenase superfamily, is a protein that hydoxylates a specific asparagine residue (Asn-803) within the HIF1alpha C-terminal transactivation domain. In normoxia, the HIF1AN-mediated hydroxylation of the HIF1alpha transactivation domain results in blockage of the HIF1alpha-p300/CBP interaction and represses transcriptional activity of HIF1alpha-targeted genes. Recombinant human HIF1AN protein was expressed in E. coli and purified by using conventional chromatography techniques. Alternative Names: HIFAN 1, FIH 1 protein, DKFZp762F1811 protein, Hypoxia-inducible factor 1 protein, HIFAN-1, Hypoxia-inducible factor asparagine hydroxylase protein, Hypoxia inducible factor 1 alpha subunit inhibitor protein, alpha subunit inhibitor Hypoxia inducible factor asparagine hydroxylase protein, Factor inhibiting HIF1 protein, Peptide aspartate beta dioxygenase protein, HIFAN-1 protein, HIFAN 1 protein, FLJ22027 protein, FLJ20615 protein, Hypoxia inducible factor 1 alpha inhibitor protein, FIH1 protein, Factor inhibiting HIF-1 protein, Hypoxia-Inducible Factor-1 Alpha Inhibitor, HIF1AN