Insulin Receptor Protein (INSR) (AA 999-1362)
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Quick Overview for Insulin Receptor Protein (INSR) (AA 999-1362) (ABIN7939178)
抗原
See all Insulin Receptor (INSR) 蛋白蛋白类型
宿主
资源
应用范围
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产品特性
- AA 999-1362
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原理
- Recombinant INSR (999-1362) protein
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Insulin Receptor (INSR) (AA 28-944) (Active) protein (His tag)
INSR 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Insulin Receptor (INSR) (AA 881-980) protein (GST tag)INSR 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Insulin Receptor (INSR) (Active) protein (GST tag,His tag)INSR 宿主: 人 宿主: Baculovirus infected Insect Cells Recombinant > 92 % as determined by reducing SDS-PAGE. Active
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Recombinant INSR (999-1362) protein is supplied in 25 mM HEPES-NaOH pH 7.5, 300 mM NaCl, 10 % glycerol, 0.04 % Triton X-100, and 0.5 mM TCEP.
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注意事项
- Avoid repeated freeze/thaw cycles,keep on ice when not in storage
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储存条件
- -80 °C
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储存方法
- Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
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- Insulin Receptor (INSR)
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别名
- INSR
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背景
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Protein Background: INSR (Insulin Receptor) is a receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosine residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson Mendenhall syndrome.
Short Description: Recombinant INSR (999-1362) protein that includes amino acids 999-1362 of human INSR protein (accession number NP_000199.2) was expressed in a baculovirus expression system, and contains an N-terminal FLAG tag. The molecular weight of the protein is 42.3 kDa.
Aliases: Insulin receptor, CD220
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途径
- NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity
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