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CTLA4 Protein (AA 36-161)

Name: CTLA4 Protein (AA 36-161)
Brand: antibodies-online
SKU: ABIN7566055
Availability: OutOfStock

This Recombinant CTLA4 protein is expressed in HEK-293 Cells.

产品编号 ABIN7566055

发货至: 中国

Quick Overview for CTLA4 Protein (AA 36-161) (ABIN7566055)

抗原

See all CTLA4 蛋白

CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

蛋白类型

Recombinant

生物活性

Active

宿主

人

资源

HEK-293 Cells

纯度

>95 % (SDS-PAGE)

Discover our top product CTLA4 蛋白

产品特性

AA 36-161

原理

CD152 [CTLA-4] (human) (rec.) (untagged)

交叉反应

人

产品特性

Human CD152 [CTLA-4] (aa 36-161) is untagged.

内毒素水平

<0.01EU/μg purified protein (LAL test).

Biological Activity Comment

Binds to human CD80.
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Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) protein (Fc Tag)
CTLA4 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) protein (mFc-His Tag)
CTLA4 宿主: 人宿主: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) protein (His tag)
CTLA4 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-161) protein (His-Avi Tag,Biotin)
CTLA4 宿主: 人宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-160) protein (His tag)
CTLA4 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-162) (Active) protein (His tag)
CTLA4 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-160) (Active) protein (Fc Tag)
CTLA4 宿主: 人宿主: HEK-293 Cells Recombinant >98 % as determined by SDS-PAGE. Active

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 36-162) (Active) protein (His tag)
CTLA4 宿主: 小鼠宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (AA 37-162) (Active) protein (Fc Tag,AVI tag,Biotin)
CTLA4 宿主: 人宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE. Active

Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4) (Active) protein (His tag)
CTLA4 宿主: 小鼠宿主: 人细胞 Recombinant > 95 % as determined by SDS-PAGE Active

限制

仅限研究用
状态

Lyophilized

溶解方式

1 mg/mL after reconstitution.

浓度

1 mg/mL

缓冲液

Contains PBS.

注意事项

After opening, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution.

储存条件

4 °C,-20 °C

储存方法

Short Term Storage: +4°C
Long Term Storage: -20°C
Use & Stability: Stable for at least 6 months after receipt when stored at -20°C.Working aliquots are stable for up to 3 months when stored at -20°C.
抗原

CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

别名

CD152 [CTLA-4]

背景

Cytotoxic T-lymphocyte-associated Antigen 4, Cytotoxic T-lymphocyte Protein 4
CD152 (Cytotoxic T-lymphocyte-associated protein 4, CTLA-4) is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T cells. Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitory response, respectively. Because of its dampening effect, CTLA-4 is a crucial regulator of T cell homeostasis and self-tolerance. While CD28 promotes T cell activation and proliferation, CTLA-4 is reported to dampen T cell responses through a variety of mechanisms. Prior to activation, conventional T cells (Tconv) express low levels of CTLA-4, predominantly in intracellular compartments. Upon activation, CTLA-4 expression is upregulated and becomes increasingly detectable on the cell surface. In Tregs on the other hand, transmembrane CTLA-4 is constitutively expressed and plays an important role in Treg homeostasis and function. In general, T cell CTLA-4 is largely constrained to intracellular expression although some surface expression may be detectable owing to the rapid, continuous shuttling of CTLA-4 between intracellular compartments and the plasma membrane. Recently, CTLA-4 has been studied in dendritic cells and tumors, showing that CTLA-4 plays nonredundant and critical roles in thymic development, T cell priming, peripheral tolerance, and a variety of other critical immunoregulatory functions as an immune checkpoint in Immuno-oncology research.

分子量

~18kDa (SDS-PAGE)

UniProt

P16410

途径

Cancer Immune Checkpoints