Myeloperoxidase Protein (MPO) (AA 49-745) (His tag)
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- 抗原 See all Myeloperoxidase (MPO) 蛋白
- Myeloperoxidase (MPO)
- 蛋白类型
- Recombinant
- 产品特性
- AA 49-745
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Myeloperoxidase protein is labelled with His tag.
- 序列
- Ala49-Ser745
- 产品特性
- Recombinant Human Myeloperoxidase is produced by our Mammalian expression system and the target gene encoding Ala49-Ser745 is expressed with a 10His tag at the C-terminus.
- 纯度
- >95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- <1.0 EU per μg of the protein as determined by the LAL method.
- Top Product
- Discover our top product MPO 蛋白
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Myeloperoxidase (MPO) (AA 646-745) protein (GST tag)
MPO 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Myeloperoxidase (MPO) protein (His tag)MPO 宿主: 小鼠 宿主: 人细胞 Recombinant > 90 % as determined by reducing SDS-PAGE.
Myeloperoxidase (MPO) (AA 165-278) protein (His tag)Crystallography grade MPO 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Myeloperoxidase (MPO) (AA 139-252) protein (His tag)Crystallography grade MPO 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Myeloperoxidase (MPO) (AA 155-745) protein (His tag)Crystallography grade MPO 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Myeloperoxidase (MPO) (AA 165-745) protein (His tag)Crystallography grade MPO 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Myeloperoxidase (MPO) (AA 279-745) protein (His tag)Crystallography grade MPO 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Myeloperoxidase (MPO) (AA 49-745) protein (His tag)Crystallography grade MPO 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Myeloperoxidase (MPO) (AA 139-718) protein (His tag)Crystallography grade MPO 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Myeloperoxidase (MPO) (AA 253-718) protein (His tag)Crystallography grade MPO 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- Myeloperoxidase (MPO)
- 别名
- Myeloperoxidase (MPO 产品)
- 别名
- mKIAA4033 Protein, MPO Protein, LOC100335032 Protein, POX2' Protein, XPOX2' Protein, mpo Protein, mpo-A Protein, pmr-1 Protein, pmr1 Protein, pox2 Protein, xpox2 Protein, myeloperoxidase Protein, myeloperoxidase L homeolog Protein, MPO Protein, Mpo Protein, LOC100335032 Protein, mpo.L Protein
- 背景
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Background: Myeloperoxidase (MPO) is a heme-containing enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxide-dependent conversion of chloride, bromide, and iodide to multiple reactive species. Post-translational processing of MPO involves the insertion of a heme moiety and the proteolytic removal of both a propeptide and a 6 aa internal peptide. This results in a disulfide-linked dimer composed of a 60 kDa heavy and 12 kDa light chain that associate into a 150 kDa enzymatically active tetramer. The tetramer contains two heme groups and one disulfide bond between the heavy chains. Alternate splicing generates two additional isoforms of MPO, one with a 32 aa insertion in the light chain, and another with a deletion of the signal sequence and part of the propeptide. Human and mouse MPO share 87 % aa sequence identity. MPO activity results in protein nitrosylation and the formation of 3-chlorotyrosine and dityrosine crosslinks. MPO is also associated with a variety of other diseases, and inhibits vasodilation in inflammation by depleting the levels of NO. Serum albumin functions as a carrier protein during MPO movement to the basolateral side of epithelial cells. MPO is stored in neutrophil azurophilic granules. Upon cellular activation, it is deposited into pathogen-containing phagosomes.
Synonym: Myeloperoxidase, MPO
- 分子量
- 80.3 kDa
- UniProt
- P05164
- 途径
- Chromatin Binding
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