Myeloperoxidase Protein (MPO) (AA 16-718) (His tag)
This Recombinant Myeloperoxidase protein is expressed in HEK-293 Cells.
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产品编号 ABIN7320799
发货至:
中国
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Quick Overview for Myeloperoxidase Protein (MPO) (AA 16-718) (His tag) (ABIN7320799)
抗原
See all Myeloperoxidase (MPO) 蛋白
Myeloperoxidase (MPO)
蛋白类型
Recombinant
宿主
小鼠
资源
HEK-293 Cells
纯度
> 95 % as determined by reducing SDS-PAGE.
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产品特性
- AA 16-718
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标记
- This Myeloperoxidase protein is labelled with His tag.
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原理
- Recombinant Mouse Myeloperoxidase/MPO Protein (His Tag)
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序列
- Met16-Thr718
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产品特性
- Recombinant Mouse Myeloperoxidase is produced by our Mammalian expression system and the target gene encoding Met16-Thr718 is expressed with a 10His tag at the C-terminus.
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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Biological Activity Comment
- Not validated for activity
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Myeloperoxidase (MPO) (AA 646-745) protein (GST tag)
MPO 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
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Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization. -
储存条件
- 4 °C,-20 °C,-80 °C
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储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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有效期
- 12 months
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- Myeloperoxidase (MPO)
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别名
- Myeloperoxidase/MPO
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背景
- MPO,Myeloperoxidase,Myeloperoxidase (MPO) is a hemecontaining enzyme belonging to the XPO subfamily of peroxidases. It is an abundant neutrophil and monocyte glycoprotein that catalyzes the hydrogen peroxidedependent conversion of chloride, bromide, and iodide to multiple reactive species. MPO activity results in protein nitrosylation and the formation of 3-chlorotyrosine and dityrosine crosslinks. Modification of ApoB100, as well as the lipid and cholesterol components of LDL and HDL, promotes the development of atherosclerosis. MPO is also associated with a variety of other diseases, and inhibits vasodilation in inflammation by depleting the levels of NO. Serum albumin functions as a carrier protein during MPO movement to the basolateral side of epithelial cells. MPO is stored in neutrophil azurophilic granules. Upon cellular activation, it is deposited into pathogencontaining phagosomes. While mice lacking MPO are impaired in clearing select microbial infections,MPO deficiency in humans does not necessarily result in heightened susceptibility to infections.
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分子量
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Calculated MW: 81.1 kDa
Observed MW: 90-100 kDa
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UniProt
- P11247
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途径
- Chromatin Binding
抗原
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