RAGE Protein (AA 23-342) (His tag)
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- 抗原 See all RAGE (AGER) 蛋白
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- 蛋白类型
- Recombinant
- 产品特性
- AA 23-342
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This RAGE protein is labelled with His tag.
- 序列
- Ala23-Ala342
- 产品特性
- A DNA sequence encoding theHuman AGER protein (Q15109) (Ala23-Ala342 ) was expressed with a N-His.
- 纯度
- >85 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product AGER 蛋白
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Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-340) protein (His tag)
AGER 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-344) protein (His tag)AGER 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-342) protein (His tag)AGER 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-342) protein (His-DYKDDDDK-Strep II Tag)AGER 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 362-404) protein (His-IF2DI Tag)AGER 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 134-231) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-404) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 87-197) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-237) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Advanced Glycosylation End Product-Specific Receptor (AGER) (Active) protein (His tag)AGER 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 96 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- 别名
- AGER (AGER 产品)
- 别名
- RAGE Protein, AGER Protein, advanced glycosylation end-product specific receptor Protein, advanced glycosylation end product-specific receptor Protein, MAPK/MAK/MRK overlapping kinase Protein, AGER Protein, Ager Protein, LOC719012 Protein
- 背景
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Background: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key pro-inflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling.Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.
Synonym: Receptor for advanced glycosylation end products
- 分子量
- 34 kDa
- UniProt
- Q15109
- 途径
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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