RAGE Protein (His tag)
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- 抗原 See all RAGE (AGER) 蛋白
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This RAGE protein is labelled with His tag.
- 原理
- Recombinant Mouse AGER/RAGE Protein (His Tag)(Active)
- 序列
- Met 1-Ala 342
- 产品特性
- A DNA sequence encoding the extracellular domain of mouse AGER (NP_031451.2) extracellular domain (Met 1-Ala 342) was expressed, with a polyhistidine tag at the C-terminus.
- 纯度
- > 96 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind mouse HMGB1-Fc in functional ELISA.
- Top Product
- Discover our top product AGER 蛋白
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Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-340) protein (His tag)
AGER 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-344) protein (His tag)AGER 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-342) protein (His tag)AGER 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-342) protein (His-DYKDDDDK-Strep II Tag)AGER 宿主: 人 宿主: HEK-293T Cells Recombinant WB, SDS, ELISA, PI
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 362-404) protein (His-IF2DI Tag)AGER 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 134-231) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-404) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 87-197) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 1-237) protein (GST tag)AGER 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Advanced Glycosylation End Product-Specific Receptor (AGER) (AA 23-342) protein (His tag)Crystallography grade AGER 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))
- 别名
- AGER/RAGE (AGER 产品)
- 别名
- RAGE Protein, AGER Protein, advanced glycosylation end-product specific receptor Protein, advanced glycosylation end product-specific receptor Protein, MAPK/MAK/MRK overlapping kinase Protein, AGER Protein, Ager Protein, LOC719012 Protein
- 背景
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Background: Receptor for Advanced Glycosylation End Products (RAGE, or AGER) is a member of the immunoglobulin super-family transmembrane proteins, as a signal transduction receptor which binds advanced glycation endproducts, certain members of the S100/calgranulin family of proteins, high mobility group box 1 (HMGB1), advanced oxidation protein products, and amyloid (beta-sheet fibrils). Initial studies investigating the role of RAGE in renal dysfunction focused on diabetes, neurodegenerative disorders, and inflammatory responses. However, RAGE also has roles in the pathogenesis of renal disorders that are not associated with diabetes, such as obesity-related glomerulopathy, doxorubicin-induced nephropathy, hypertensive nephropathy, lupus nephritis, renal amyloidosis, and ischemic renal injuries. RAGE represents an important factor in innate immunity against pathogens, but it also interacts with endogenous ligands, resulting in chronic inflammation. RAGE signaling has been implicated in multiple human illnesses, including atherosclerosis, arthritis, Alzheimer's disease, atherosclerosis and aging associated diseases.
Synonym: RAGE
- 分子量
- 35.3 kDa
- NCBI登录号
- NP_031451
- 途径
- Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins
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