FYN Protein (AA 82-246) (His tag)
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- 抗原 See all FYN 蛋白
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
- 蛋白类型
- Recombinant
- 产品特性
- AA 82-246
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This FYN protein is labelled with His tag.
- 序列
- Thr82-Cys246
- 产品特性
- A DNA sequence encoding theHuman Fyn protein (P06241) (Thr82-Cys246) was expressed with a N-His.
- 纯度
- >85 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product FYN 蛋白
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FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-482) protein (GST tag)
FYN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP, KAA
FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-537) (Active) protein (His-GST)FYN 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 41-190) protein (His-IF2DI Tag)FYN 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 1-90) protein (GST tag)FYN 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 2-537) protein (His tag)Crystallography grade FYN 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
FYN Oncogene Related To SRC, FGR, YES (FYN) (AA 2-537) protein (His tag)Crystallography grade FYN 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
FYN Oncogene Related To SRC, FGR, YES (FYN) (Transcript Variant 1) (Active) protein (Myc-DYKDDDDK Tag)FYN 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining Func, AbP, STD, PI Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
- 有效期
- 12 months
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- 抗原
- FYN (FYN Oncogene Related To SRC, FGR, YES (FYN))
- 别名
- Fyn (FYN 产品)
- 别名
- im:6908851 Protein, si:dkey-119m7.5 Protein, zgc:109996 Protein, c-fyn Protein, cfyn-a Protein, SLK Protein, SYN Protein, p59-FYN Protein, PKC Protein, fyn Protein, zgc:86720 Protein, AI448320 Protein, AW552119 Protein, FYN proto-oncogene, Src family tyrosine kinase Protein, FYN proto-oncogene, Src family tyrosine kinase S homeolog Protein, FYN proto-oncogene, Src family tyrosine kinase b Protein, FYN proto-oncogene, Src family tyrosine kinase L homeolog Protein, FYN proto-oncogene, Src family tyrosine kinase a Protein, Fyn proto-oncogene Protein, FYN Protein, fyn.S Protein, fynb Protein, fyn.L Protein, Fyn Protein, fyna Protein
- 背景
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Background: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL1 and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Phosphorylates PTK2B/PYK2 in response to T-cell receptor activation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1. In mast cells, phosphorylates CLNK after activation of immunoglobulin epsilon receptor signaling.
Synonym: Proto-oncogene Syn,Proto-oncogene c-Fyn,Src-like kinase,SLK,p59-Fyn
- 分子量
- 19 kDa
- UniProt
- P06241
- 途径
- JAK/STAT Signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Feeding Behaviour, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Activated T Cell Proliferation, Thromboxane A2 Receptor Signaling
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