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LILRA4 Protein (His tag)

LILRA4 宿主: 人 宿主: HEK-293 Cells Recombinant 90 %
产品编号 ABIN7489015
发货至: 中国
  • 抗原 See all LILRA4 蛋白
    LILRA4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 4 (LILRA4))
    蛋白类型
    Recombinant
    宿主
    • 6
    • 1
    资源
    • 3
    • 2
    • 2
    HEK-293 Cells
    标记
    This LILRA4 protein is labelled with His tag.
    原理
    Human LILRA4 / CD85g / ILT7 Protein, His Tag
    序列
    Glu 24 - Asn 446
    产品特性
    Human LILRA4 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Glu 24 - Asn 446 (Accession # P59901-1).
    纯度
    90 %
    内毒素水平
    1.0 EU per μg
    Top Product
    Discover our top product LILRA4 蛋白
  • 说明

    This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 48.5 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

    限制
    仅限研究用
  • 状态
    Lyophilized
    缓冲液
    PBS, pH 7.4
    储存条件
    -20 °C
    储存方法
    -20°C
  • 抗原
    LILRA4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 4 (LILRA4))
    别名
    LILRA4 (LILRA4 产品)
    别名
    ILT7 Protein, CD85g Protein, leukocyte immunoglobulin like receptor A4 Protein, LILRA4 Protein
    背景
    Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4/ILT7/CD85g) is a marker of plasmacytoid dendritic cells (pDCs), which are reported to be a major source of the abnormally high levels of IFNα associated with autoimmune diseases. Targeting LILRA4 with therapeutic antibodies to promote killing of these IFNα-producing pDCs is being investigated as a novel approach to alleviating the symptoms of autoimmune diseases. LILRA4 is an immunoglobulin-like protein preferentially expressed on the surface of human plasmacytoid dendritic cells (pDCs). It interacts with bone marrow stromal cell antigen 2 to control the Toll-like receptor (TLR) driven response by pDCs to viral infection. It may also be involved in modulating pDC-tumour interactions. pDCs are a source of the excess IFNα which drives autoimmune disease symptoms.
    分子量
    48.5 kDa
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