LILRA4 Protein (His tag)
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- 抗原 See all LILRA4 蛋白
- LILRA4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 4 (LILRA4))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This LILRA4 protein is labelled with His tag.
- 原理
- Human LILRA4 / CD85g / ILT7 Protein, His Tag
- 序列
- Glu 24 - Asn 446
- 产品特性
- Human LILRA4 Protein, His Tag is expressed from human 293 cells (HEK293). It contains AA Glu 24 - Asn 446 (Accession # P59901-1).
- 纯度
- 90 %
- 内毒素水平
- 1.0 EU per μg
- Top Product
- Discover our top product LILRA4 蛋白
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- 说明
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This protein carries a polyhistidine tag at the C-terminus. (10xHis) The protein has a calculated MW of 48.5 kDa. The protein migrates as 60-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 缓冲液
- PBS, pH 7.4
- 储存条件
- -20 °C
- 储存方法
- -20°C
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- 抗原
- LILRA4 (Leukocyte Immunoglobulin-Like Receptor, Subfamily A (With TM Domain), Member 4 (LILRA4))
- 别名
- LILRA4 (LILRA4 产品)
- 别名
- ILT7 Protein, CD85g Protein, leukocyte immunoglobulin like receptor A4 Protein, LILRA4 Protein
- 背景
- Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILRA4/ILT7/CD85g) is a marker of plasmacytoid dendritic cells (pDCs), which are reported to be a major source of the abnormally high levels of IFNα associated with autoimmune diseases. Targeting LILRA4 with therapeutic antibodies to promote killing of these IFNα-producing pDCs is being investigated as a novel approach to alleviating the symptoms of autoimmune diseases. LILRA4 is an immunoglobulin-like protein preferentially expressed on the surface of human plasmacytoid dendritic cells (pDCs). It interacts with bone marrow stromal cell antigen 2 to control the Toll-like receptor (TLR) driven response by pDCs to viral infection. It may also be involved in modulating pDC-tumour interactions. pDCs are a source of the excess IFNα which drives autoimmune disease symptoms.
- 分子量
- 48.5 kDa
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