Adenosine A2a Receptor Protein (ADORA2A)
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- 抗原 See all Adenosine A2a Receptor (ADORA2A) 蛋白
- Adenosine A2a Receptor (ADORA2A)
- 蛋白类型
- Synthetic
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宿主
- 人
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资源
- HEK-293 Cells
- 原理
- Human ADORA2A full length protein-synthetic nanodisc
- 产品特性
- Full Length Transmembrane Proteins (synthetic Nanodisc)
- Top Product
- Discover our top product ADORA2A 蛋白
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Adenosine A2a Receptor (ADORA2A) (AA 1-412) (Active) protein-VLP
ADORA2A 宿主: 人 宿主: HEK-293 Cells VLP > 95 % as determined by HPLC ELISA, Imm, Func, SPR Active
Adenosine A2a Receptor (ADORA2A) (AA 1-412) protein (GST tag)ADORA2A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Adenosine A2a Receptor (ADORA2A) (AA 147-267) protein (GST tag)ADORA2A 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Adenosine A2a Receptor (ADORA2A) (AA 1-412) protein (Strep Tag)Crystallography grade ADORA2A 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
Adenosine A2a Receptor (ADORA2A) (AA 1-410) protein (Strep Tag)Crystallography grade ADORA2A 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS
Adenosine A2a Receptor (ADORA2A) (AA 286-410) protein (His tag)Crystallography grade ADORA2A 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
Adenosine A2a Receptor (ADORA2A) (AA 291-412) protein (His tag)Crystallography grade ADORA2A 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, ELISA, SDS, Crys
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- 应用备注
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- Applications for VLPs:
- ELISA
- SPR affinity analysis
- Phage display screening
- Immunization
- Cell based assays
- CAR-T cell screening
- Protein cystal structure analysis
- 说明
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Synthetic Nanodisc can be prepared directly from the cells. The polymers used during this process have a dual function. It dissolves the cell membranes, like the detergent, and uses cellular phospholipids to form Nanodisc around the membrane proteins. The target protein embedded Nanodiscs can then be purified.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Supplied in nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0)
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
- 有效期
- 12 months
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- 抗原
- Adenosine A2a Receptor (ADORA2A)
- 别名
- ADORA2A (ADORA2A 产品)
- 别名
- ADORA2A Protein, adora2a.1 Protein, zgc:194773 Protein, A2aR Protein, ADORA2 Protein, RDC8 Protein, A2AAR Protein, AA2AR Protein, A2ar Protein, ADENO Protein, Adora2l1 Protein, adora2a.2 Protein, zgc:193802 Protein, zgc:193822 Protein, adenosine A2a receptor Protein, adenosine A2a receptor a Protein, adenosine A2a receptor L homeolog Protein, adenosine A2a receptor b Protein, ADORA2A Protein, Adora2a Protein, adora2aa Protein, adora2a.L Protein, adora2a Protein, adora2ab Protein
- 背景
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A2aR, ADORA2,
Description: RDC8A member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. - 分子量
- The human full length ADORA2A protein has a MW of 44.7 kDa
- UniProt
- P29274
- 途径
- Neurotrophin Signaling Pathway, cAMP Metabolic Process, Synaptic Membrane, Feeding Behaviour, Cancer Immune Checkpoints
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