WISP1 Protein (AA 23-367) (His tag)
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- 抗原 See all WISP1 蛋白
- WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
- 蛋白类型
- Recombinant
- 产品特性
- AA 23-367
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This WISP1 protein is labelled with His tag.
- 原理
- Mouse WISP1 Protein
- 序列
- Thr23-Asn367
- 产品特性
- Recombinant Mouse WISP1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Thr23-Asn367.
- 纯度
- > 95 % as determined by Tris-Bis PAGE
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
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WNT1 Inducible Signaling Pathway Protein 1 (WISP1) (AA 1-280) protein (GST tag)
WISP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
WNT1 Inducible Signaling Pathway Protein 1 (WISP1) (Transcript Variant 1) (Active) proteinWISP1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD, Func, PI Active
WNT1 Inducible Signaling Pathway Protein 1 (WISP1) proteinWISP1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % WB, SDS, ELISA, IP
WNT1 Inducible Signaling Pathway Protein 1 (WISP1) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)WISP1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- WISP1 (WNT1 Inducible Signaling Pathway Protein 1 (WISP1))
- 别名
- WISP1 (WISP1 产品)
- 别名
- CCN4 Protein, WISP1c Protein, WISP1i Protein, WISP1tc Protein, WISP-1 Protein, WISP1 Protein, si:ch211-38f10.2 Protein, AW146261 Protein, Elm1 Protein, zgc:172276 Protein, WNT1 inducible signaling pathway protein 1 Protein, WNT1 inducible signaling pathway protein 1a Protein, WNT1-inducible-signaling pathway protein 1-like Protein, WNT1 inducible signaling pathway protein 1b Protein, WISP1 Protein, wisp1a Protein, Wisp1 Protein, LOC100627044 Protein, wisp1b Protein
- 背景
- The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.
- 分子量
- 39.4 kDa. Due to glycosylation, the protein migrates to 64-68 kDa based on Tris-Bis PAGE result.
- UniProt
- O54775
- 途径
- WNT signaling, Growth Factor Binding
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