Complement Factor H Protein (CFH) (AA 860-1231) (His tag)
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- 抗原 See all Complement Factor H (CFH) 蛋白
- Complement Factor H (CFH)
- 蛋白类型
- Recombinant
- 产品特性
- AA 860-1231
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This Complement Factor H protein is labelled with His tag.
- 原理
- Human Factor H/CFH Protein
- 序列
- Ser860-Arg1231
- 产品特性
- Recombinant Human Factor H/CFH Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Ser860-Arg1231.
- 纯度
- > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
- 过滤
- 0.22 μm filtered
- 内毒素水平
- Less than 1EU per μg by the LAL method.
- Biological Activity Comment
- Immobilized Human Factor H, His Tag at 0.2μg/ml (100μl/well) on the plate. Dose response curve for Anti-Factor H Antibody, hFc Tag with the EC50 of 14.8ng/ml determined by ELISA. See testing image for detail.
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Complement Factor H (CFH) (AA 875-1252) protein (His tag)
CFH 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Complement Factor H (CFH) (AA 20-449) protein (GST tag)CFH 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Complement Factor H (CFH) (AA 1-449) protein (GST tag)CFH 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Complement Factor H (CFH) (AA 19-1231) protein (His tag)Crystallography grade CFH 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Complement Factor H (CFH) (AA 19-1234) protein (His tag)Crystallography grade CFH 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/mL is recommended. Dissolve the lyophilized protein in distilled water.
- 缓冲液
- Lyophilized from 0.22μm filtered solution in PBS ( pH 7.4). Normally 8 % trehalose is added as protectant before lyophilization.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- -20 to -80°C for 12 months as supplied from date of receipt.,-80°C for 3-6 months after reconstitution.,2-8°C for 2-7 days after reconstitution.,Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- Complement Factor H (CFH)
- 别名
- Factor H (CFH 产品)
- 别名
- AHUS1 Protein, AMBP1 Protein, ARMD4 Protein, ARMS1 Protein, CFHL3 Protein, FH Protein, FHL1 Protein, HF Protein, HF1 Protein, HF2 Protein, HUS Protein, Mud-1 Protein, NOM Protein, Sas-1 Protein, Sas1 Protein, Fh Protein, CFH Protein, im:7147412 Protein, si:ch211-207o17.2 Protein, fH Protein, armd4 Protein, arms1 Protein, cfh Protein, cfhl3 Protein, fhl1 Protein, hf1 Protein, hf2 Protein, hus Protein, complement factor H Protein, complement component factor h Protein, complement factor H-related protein 5 Protein, complement factor H L homeolog Protein, CFH Protein, Cfh Protein, cfh Protein, LOC100399888 Protein, LOC100733902 Protein, cfh.L Protein
- 背景
- Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self) can hijack factor H to evade the immune response.
- 分子量
- 42.8 kDa. Due to glycosylation, the protein migrates to 60-68 kDa based on Tris-Bis PAGE result.
- 途径
- Complement System, Cellular Response to Molecule of Bacterial Origin
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