DDR2 Protein (GST tag,His tag)
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- 抗原 See all DDR2 蛋白
- DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This DDR2 protein is labelled with GST tag,His tag.
- 原理
- Recombinant Human DDR2 Kinase/CD167b Protein (aa 422-855, His & GST Tag)(Active)
- 序列
- Arg422-Glu855
- 产品特性
- A DNA sequence encoding the human DDR2 (Q16832) (Arg422-Glu855) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- The specific activity was determined to be 8 nmol/min/mg using synthetic AXLtide peptide(CKKSRGDYMTMQIG) as substrate.
- Top Product
- Discover our top product DDR2 蛋白
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Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 22-399) protein (His tag)
DDR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 22-399) protein (His tag)DDR2 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 422-855) (Active) protein (His-GST)DDR2 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) protein (His tag)DDR2 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 1-855) protein (GST tag)DDR2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 277-377) protein (GST tag)DDR2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (Active) protein (His tag)DDR2 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (Active) protein (Fc Tag)DDR2 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE Active
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 22-399) protein (His tag)Crystallography grade DDR2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 22-399) protein (His tag)Crystallography grade DDR2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 说明
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77 kDa
- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- DDR2 (Discoidin Domain Receptor tyrosine Kinase 2 (DDR2))
- 别名
- CD167b (DDR2 产品)
- 别名
- MIG20a Protein, NTRKR3 Protein, TKT Protein, TYRO10 Protein, AW495251 Protein, Ntrkr3 Protein, tyro10 Protein, DDR2 Protein, Tyro10 Protein, ddr2 Protein, si:ch211-193c2.1 Protein, discoidin domain receptor tyrosine kinase 2 Protein, discoidin domain receptor family, member 2 Protein, discoidin domain receptor family, member 2, like Protein, DDR2 Protein, Ddr2 Protein, ddr2l Protein
- 背景
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Background: Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Synonym: CD167;MIG20a;NTRKR3;TKT;TYRO10
- 分子量
- 77.1 kDa
- UniProt
- Q16832
- 途径
- RTK signaling
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