VLDLR Protein (His tag)
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- 抗原 See all VLDLR 蛋白
- VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This VLDLR protein is labelled with His tag.
- 原理
- Recombinant Human VLDLR/VLDL Receptor Protein (His Tag)(Active)
- 序列
- Met 1-Ser 797
- 产品特性
- A DNA sequence encoding the human VLDLR isoform alpha (NP_003374.3) extracellular domain (Met 1-Ser 797) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its binding ability in a functional ELISA.Immobilized human VLDLR-His at 10μg/mL (100μL/well) can bind biotinylated human LRPAP1-His, the EC50 of biotinylated human LRPAP1-His is 0.05-0.2 μg/mL.
- Top Product
- Discover our top product VLDLR 蛋白
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Very Low Density Lipoprotein Receptor (VLDLR) (AA 28-797) protein (His tag)
VLDLR 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Very Low Density Lipoprotein Receptor (VLDLR) (AA 28-797) protein (His tag)VLDLR 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Very Low Density Lipoprotein Receptor (VLDLR) (AA 28-797) protein (His tag)Crystallography grade VLDLR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Very Low Density Lipoprotein Receptor (VLDLR) (AA 28-873) protein (rho-1D4 tag)Crystallography grade VLDLR 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Very Low Density Lipoprotein Receptor (VLDLR) (AA 28-769) (Active) protein (His tag)VLDLR 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))
- 别名
- VLDLR/VLDL Receptor (VLDLR 产品)
- 别名
- CARMQ1 Protein, CHRMQ1 Protein, VLDLRCH Protein, AA408956 Protein, AI451093 Protein, AW047288 Protein, vldlr Protein, very low density lipoprotein receptor Protein, very low density lipoprotein receptor S homeolog Protein, VLDLR Protein, Vldlr Protein, vldlr.S Protein
- 背景
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Background: The very low density lipoprotein receptor, known as VLDLR, is a single-pass type 1 integral membrance protein and a member of the LDL receptor family. This receptor family includes LDL receptor, LRP, megalin, VLDLR and ApoER2, and is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR contains 3 EGF-like domains, 8 LDL-receptor class A domains, as well as 6 LDL-receptor class B repeats, and is abundant in heart, skeletal muscle, also ovary and kidney, but not in liver. VLDLR binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. VLDLR mediates the phosphorylation of mDab1 (mammalian disabled protein) via binding to Reelin, and induces the modulation of Tau phosphorylation. This pathway regulates the migration of neurons along the radial glial fiber network during brain development. Defects of VLDLR may be the cause of VLDLR-associated cerebellar hypoplasia (VLDLRCH), a syndrome characterized by moderate-to-profound mental retardation, delayed ambulation, and predominantly truncal ataxia.
Synonym: CAMRQ1,CARMQ1,CHRMQ1,VLDLRCH
- 分子量
- 86 kDa
- NCBI登录号
- NP_003374
- 途径
- Cellular Response to Molecule of Bacterial Origin
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