DcR2 Protein (Fc Tag)
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- 抗原 See all DcR2 (TNFRSF10D) 蛋白
- DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
- 蛋白类型
- Recombinant
- 宿主
- 人
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资源
- 人细胞
- 标记
- This DcR2 protein is labelled with Fc Tag.
- 原理
- Recombinant Human TRAIL R4/TNFRSF10D Protein (Fc Tag)
- 序列
- Ala56-His211
- 产品特性
- Recombinant Human TRAILR4 is produced by our Mammalian expression system and the target gene encoding Ala56-His211 is expressed with a Fc tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product TNFRSF10D 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- DcR2 (TNFRSF10D) (Tumor Necrosis Factor Receptor Superfamily, Member 10d, Decoy with Truncated Death Domain (TNFRSF10D))
- 别名
- TRAIL R4/TNFRSF10D (TNFRSF10D 产品)
- 别名
- TNFRSF10D Protein, CD264 Protein, DCR2 Protein, TRAIL-R4 Protein, TRAILR4 Protein, TRUNDD Protein, TNF receptor superfamily member 10d Protein, tumor necrosis factor receptor superfamily member 10D Protein, TNFRSF10D Protein, LOC716901 Protein
- 背景
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Background: Human TRAIL R4 is a type 1, TNF R family membrane protein, which is a receptor for TRAIL (APO2 ligand). TRAIL R4 contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplasmic death domain. In the new TNF superfamily nomenclature, TRAIL R4 is referred to as TNFRSF10D. TRAIL R4 is unique among the TRAIL receptors in that its cytoplasmic domain contains a truncated consensus death domain motif. Binding of TRAIL R4 does not result in an apoptotic signal. Overexpression of TRAIL R4 can protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL mediated apoptosis. The human soluble TRAIL R4/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.
Synonym: Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL-R4, TRAIL receptor with a truncated death domain, CD264, TNFRSF10D, DCR2, TRAILR4, TRUNDD
- 分子量
- 43.4 kDa
- UniProt
- Q9UBN6
- 途径
- Apoptosis
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