TPP1 Protein (His tag)
-
- 抗原 See all TPP1 蛋白
- TPP1 (Tripeptidyl Peptidase I (TPP1))
- 蛋白类型
- Recombinant
- 生物活性
- Active
-
宿主
- 人
-
资源
- Baculovirus infected Insect Cells
- 标记
- This TPP1 protein is labelled with His tag.
- 原理
- Recombinant Human TPP1/CLN2 Protein (His Tag)(Active)
- 序列
- Met 1-Pro 563
- 产品特性
- A DNA sequence encoding the pro form of human TPP1 (AAH14863.1) (Met 1-Pro 563) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by the cleavage of AlaAlaPheAMC. The specific activity is > 850 pmoles/min/μg.
- Top Product
- Discover our top product TPP1 蛋白
-
Tripeptidyl Peptidase I (TPP1) (AA 195-304) protein (GST tag)
TPP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
Tripeptidyl Peptidase I (TPP1) (AA 1-563) protein (GST tag)TPP1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AA, AP
-
- 限制
- 仅限研究用
-
- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 10 % glycerol
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
-
- 抗原
- TPP1 (Tripeptidyl Peptidase I (TPP1))
- 别名
- TPP1/CLN2 (TPP1 产品)
- 别名
- cln2 Protein, fa01b09 Protein, im:7149243 Protein, wu:fa01b09 Protein, CLN2 Protein, LPIC Protein, TPP-1 Protein, TPP-I Protein, Cln2 Protein, tripeptidyl peptidase I Protein, tripeptidyl-peptidase 1 Protein, tripeptidyl peptidase 1 Protein, tpp1 Protein, NAEGRDRAFT_78259 Protein, MCYG_00184 Protein, MGYG_05881 Protein, MGYG_00757 Protein, TPP1 Protein, Tpp1 Protein
- 背景
-
Background: Tripeptidyl-peptidase 1 (TPP1 / CLN2) is a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. TPP1 / CLN2 May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Defects in TPP1 / CLN2 are the cause of neuronal ceroid lipofuscinosis type 2 (CLN2), a form of neuronal ceroid lipofuscinosis which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material, and clinically by seizures, dementia, visual loss, and/or cerebral atrophy.
Synonym: Tripeptidyl-Peptidase 1, TPP-1, Cell Growth-Inhibiting Gene 1 Protein, Lysosomal Pepstatin-Insensitive Protease, LPIC, Tripeptidyl Aminopeptidase, TPP1, CLN2,GIG1,LPIC,SCAR7,TPP-1
- 分子量
- 60.7 kDa
- 途径
- Cell Division Cycle, ER-Nucleus Signaling
-
