TDGF1 Protein (Fc Tag)
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- 抗原 See all TDGF1 蛋白
- TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))
- 蛋白类型
- Recombinant
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宿主
- 大鼠
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资源
- HEK-293 Cells
- 标记
- This TDGF1 protein is labelled with Fc Tag.
- 原理
- Recombinant Rat TDGF1 Protein (Fc Tag)
- 序列
- Met 1-Cys 143
- 产品特性
- A DNA sequence encoding the rat TDGF1 (XP_001056317.2) (Met 1-Cys 143) was fused with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 90 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
- Top Product
- Discover our top product TDGF1 蛋白
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Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (AA 31-188) protein (GST tag)
TDGF1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (AA 18-134) protein (His tag)Crystallography grade TDGF1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (AA 32-150), (partial) protein (GST tag)TDGF1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % SDS, ELISA
Teratocarcinoma-Derived Growth Factor 1 (TDGF1) (AA 32-150), (partial) protein (His tag)TDGF1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % SDS
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- TDGF1 (Teratocarcinoma-Derived Growth Factor 1 (TDGF1))
- 别名
- TDGF1 (TDGF1 产品)
- 别名
- CR Protein, CRGF Protein, CRIPTO Protein, CR1 Protein, cripto Protein, cb85 Protein, tdgf1 Protein, wu:fe01d04 Protein, zgc:109829 Protein, Cripto-1 Protein, cr1 Protein, cr1a Protein, frl-1 Protein, frl1 Protein, xcr1 Protein, TDGF1 Protein, tdgf3 Protein, cripto-3 Protein, teratocarcinoma-derived growth factor 1 Protein, teratocarcinoma-derived growth factor 1, member 3 L homeolog Protein, teratocarcinoma-derived growth factor 1, member 1 Protein, TDGF1 Protein, Tdgf1 Protein, tdgf1 Protein, tdgf1.3.L Protein, tdgf1.1 Protein
- 背景
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Background: Cripto/TDGF1 is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. Before gastrulation, Cripto is asymmetrically expressed in a proximal–distal gradient in the epiblast, and subsequently is expressed in the primitive streak and newly formed embryonic mesoderm. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in Cripto/TDGF1 can cause autosomal visceral heterotaxy. Cripto/TDGF1 is involved in left-right asymmetric morphogenesis during organ development. Cripto signalling is essential for the conversion of a proximal–distal asymmetry into an orthogonal anterior–posterior axis. The mechanism of inhibitory effects of the Cripto includes both cancer cell apoptosis, activation of c-Jun-NH(2)-terminal kinase and p38 kinase signaling pathways and blocking of Akt phosphorylation. Thus, Cripto is a unique target, and Immunohistochemistry to Cripto could be of therapeutic value for human cancers.
Synonym: FGFR-4
- 分子量
- 41 kDa
- NCBI登录号
- XP_001056317
- 途径
- EGFR Signaling Pathway
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