TEK Protein (Fc Tag)
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- 抗原 See all TEK 蛋白
- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 大鼠
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资源
- HEK-293 Cells
- 标记
- This TEK protein is labelled with Fc Tag.
- 原理
- Recombinant Rat Tie2/TEK Protein (Fc Tag)(Active)
- 序列
- Met 4-Leu 743
- 产品特性
- A DNA sequence encoding the rat TEK (NP_001099207.1) extracellular domain (Met 4-Leu 743) was fused with the Fc region of human IgG1 at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method
- Biological Activity Comment
- 1. Measured by its binding ability in a functional ELISA.2. Immobilized S1h-3C-mANGPT2 at 10 μg/mL (100 μL/well) can bind ratTEK-Fc.The EC50 of ratTEK-Fc is 0.26-0.62μg/mL.
- Top Product
- Discover our top product TEK 蛋白
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TEK Tyrosine Kinase, Endothelial (TEK) (AA 771-1124) (Active) protein (GST tag)
TEK 宿主: 人 宿主: Insect cells (Sf9) Recombinant SDS, Func Active
TEK Tyrosine Kinase, Endothelial (TEK) (AA 23-748) (Active) protein (Fc Tag)TEK 宿主: 人 宿主: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
TEK Tyrosine Kinase, Endothelial (TEK) (AA 701-800) protein (GST tag)TEK 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
TEK Tyrosine Kinase, Endothelial (TEK) (AA 770-1122) (Active) protein (GST tag,His tag)TEK 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 91 % as determined by SDS-PAGE Active
TEK Tyrosine Kinase, Endothelial (TEK) (Active) protein (His tag)TEK 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
- 别名
- Tie2/TEK (TEK 产品)
- 别名
- TEK Protein, DKFZp469E064 Protein, AA517024 Protein, Cd202b Protein, Hyk Protein, Tie2 Protein, tie-2 Protein, CD202B Protein, TIE-2 Protein, TIE2 Protein, VMCM Protein, VMCM1 Protein, Tie-2 Protein, tie2 Protein, TEK receptor tyrosine kinase Protein, angiopoietin-1 receptor Protein, TEK tyrosine kinase, endothelial Protein, TEK Protein, LOC100408334 Protein, tek Protein, Tek Protein
- 背景
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Background: TEK, or TIE-2, is an endothelial cell-specific receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells. TEK comprises a subfamily of RTK with TIE, and these two receptors play critical roles in vascular maturation, maintenance of integrity and remodeling. Targeted mutagenesis of both Tek and its agonistic ligand, Angiopoietin-1, result in embryonic lethality, demonstrating that the signal transduction pathways mediated by this receptor are crucial for normal embryonic development. TEK signaling is indispensable for the development of the embryonic vasculature and suggests that TEK signaling may also be required for the development of the tumor vasculature.
Synonym: Tie-2,Tie2
- 分子量
- 108 kDa
- NCBI登录号
- NP_001099207
- 途径
- RTK signaling, Growth Factor Binding
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