STIM1 Protein (His tag)
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- 抗原 See all STIM1 蛋白
- STIM1 (Stromal Interaction Molecule 1 (STIM1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This STIM1 protein is labelled with His tag.
- 原理
- Recombinant Human STIM1/GOK Protein (His Tag)
- 序列
- Met 1-Asp 213
- 产品特性
- A DNA sequence encoding the human STIM1 (NP_003147.2) extracellular domain (Met 1-Asp 213) was expressed, with a polyhistidine tag at the C-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product STIM1 蛋白
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Stromal Interaction Molecule 1 (STIM1) (AA 24-685) protein (GST tag)
STIM1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Stromal Interaction Molecule 1 (STIM1) (AA 23-213) protein (CaM)STIM1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 90 % by SDS - PAGE SDS
Stromal Interaction Molecule 1 (STIM1) (AA 23-213) protein (His tag)Crystallography grade STIM1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Stromal Interaction Molecule 1 (STIM1) (AA 23-213) protein (His tag)Crystallography grade STIM1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Stromal Interaction Molecule 1 (STIM1) (AA 235-685) protein (His tag)Crystallography grade STIM1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Stromal Interaction Molecule 1 (STIM1) (AA 235-685) protein (His tag)Crystallography grade STIM1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Stromal Interaction Molecule 1 (STIM1) (AA 23-685) protein (rho-1D4 tag)Crystallography grade STIM1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Stromal Interaction Molecule 1 (STIM1) (AA 23-685) protein (rho-1D4 tag)Crystallography grade STIM1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Stromal Interaction Molecule 1 (STIM1) protein (Myc-DYKDDDDK Tag)STIM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- STIM1 (Stromal Interaction Molecule 1 (STIM1))
- 别名
- STIM1/GOK (STIM1 产品)
- 别名
- stim1 Protein, MGC76045 Protein, STIM1 Protein, si:dkey-24p1.5 Protein, MGC154748 Protein, si:ch211-112l17.2 Protein, Stim1 Protein, D11S4896E Protein, GOK Protein, TAM Protein, SIM Protein, stromal interaction molecule 1 Protein, stromal interaction molecule 1a Protein, stromal interaction molecule 1 L homeolog Protein, stromal interaction molecule 1b Protein, STIM1 Protein, stim1 Protein, stim1a Protein, stim1.L Protein, stim1b Protein, Stim1 Protein
- 背景
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Background: Stromal interaction molecule 1, also known as STIM1 and GOK, is a cell membrane, a single-pass type I membrane protein and a endoplasmic reticulum membrane protein. STIM1 / GOK is ubiquitously expressed in various human primary cells and tumor cell lines. It contains one EF-hand domain and one SAM (sterile alpha motif) domain. STIM1 / GOK plays a role in mediating Ca2+ influx following depletion of intracellular Ca2+ stores. It acts as Ca2+ sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca2+ depletion, STIM1 / GOK translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca2+ release-activated Ca2+ (CRAC) channel subunit, TMEM142A / ORAI1. Transfection of STIM1 / GOK into cells derived from a rhabdoid tumor and from a rhabdomyosarcoma that do not express detectable levels of STIM1 can induce cell death, suggesting a possible role in the control of rhabdomyosarcomas and rhabdoid tumors. Defects in STIM1 are the cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 2 (IDTICED2) which is an immune disorder characterized by recurrent infections, impaired T-cell activation and proliferative response, decreased T-cell production of cytokines, lymphadenopathy, and normal lymphocytes counts and serum immunoglobulin levels.
Synonym: D11S4896E;GOK;IMD10;STRMK;TAM;TAM1
- 分子量
- 23.3 kDa
- NCBI登录号
- NP_003147
- 途径
- TCR Signaling, BCR Signaling
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