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STIM1 Protein (Myc-DYKDDDDK Tag)

STIM1 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
产品编号 ABIN2732852
发货至: 中国
  • 抗原 See all STIM1 蛋白
    STIM1 (Stromal Interaction Molecule 1 (STIM1))
    蛋白类型
    Recombinant
    宿主
    • 7
    • 3
    • 1
    • 1
    资源
    • 6
    • 2
    • 2
    • 1
    • 1
    HEK-293 Cells
    标记
    This STIM1 protein is labelled with Myc-DYKDDDDK Tag.
    应用范围
    Antibody Production (AbP), Standard (STD)
    产品特性
    • Recombinant human STIM1 / GOK protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    纯度
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product STIM1 蛋白
  • 应用备注
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    说明

    The tag is located at the C-terminal.

    限制
    仅限研究用
  • 浓度
    50 μg/mL
    缓冲液
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    储存条件
    -80 °C
    储存方法
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • 抗原
    STIM1 (Stromal Interaction Molecule 1 (STIM1))
    别名
    Stim1,gok (STIM1 产品)
    别名
    stim1 Protein, MGC76045 Protein, STIM1 Protein, si:dkey-24p1.5 Protein, MGC154748 Protein, si:ch211-112l17.2 Protein, Stim1 Protein, D11S4896E Protein, GOK Protein, TAM Protein, SIM Protein, stromal interaction molecule 1 Protein, stromal interaction molecule 1a Protein, stromal interaction molecule 1 L homeolog Protein, stromal interaction molecule 1b Protein, STIM1 Protein, stim1 Protein, stim1a Protein, stim1.L Protein, stim1b Protein, Stim1 Protein
    背景
    This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3&apos end of this gene situated 1.6 kb from the 5&apos end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants.
    分子量
    74.8 kDa
    NCBI登录号
    NP_003147
    途径
    TCR Signaling, BCR Signaling
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