SMAD2 Protein (His tag,DYKDDDDK Tag)
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- 抗原 See all SMAD2 蛋白
- SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This SMAD2 protein is labelled with His tag,DYKDDDDK Tag.
- 原理
- Recombinant Human SMAD2 Protein (His & Flag Tag)
- 序列
- Ser2-Ser467
- 产品特性
- Recombinant Human Mothers Against Decapentaplegic Homolog 2 is produced by our E.coli expression system and the target gene encoding Ser2-Ser467 is expressed with a 6His, Flag tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product SMAD2 蛋白
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SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 181-280) protein (GST tag)
SMAD2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 2-467) protein (His tag)SMAD2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 1-467) protein (His tag)SMAD2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS
SMAD, Mothers Against DPP Homolog 2 (SMAD2) protein (GST tag,His tag)SMAD2 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE
SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 2-467) protein (His tag)Crystallography grade SMAD2 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 2-467) protein (His tag)Crystallography grade SMAD2 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
SMAD, Mothers Against DPP Homolog 2 (SMAD2) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)SMAD2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
SMAD, Mothers Against DPP Homolog 2 (SMAD2) (AA 2-467), (full length) protein (His tag)SMAD2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 90 % SDS, ELISA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,500 mM NaCl, pH 7.5.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
- 别名
- SMAD2 (SMAD2 产品)
- 别名
- JV18 Protein, JV18-1 Protein, MADH2 Protein, MADR2 Protein, hMAD-2 Protein, hSMAD2 Protein, jv18 Protein, Xmad2 Protein, madh2 Protein, madr2 Protein, XSmad2 Protein, hmad-2 Protein, hsmad2 Protein, jv18-1 Protein, smad-2 Protein, fj43c06 Protein, wu:fj43c06 Protein, 7120426M23Rik Protein, Madh2 Protein, Madr2 Protein, Smad-2 Protein, mMad2 Protein, MAD homolog 2 Protein, Mothers against DPP homolog 2 Protein, SMAD 2 Protein, Smad2 Protein, SMAD family member 2 Protein, SMAD family member 2-Z Protein, SMAD family member 2 S homeolog Protein, SMAD2 Protein, SMAD2Z Protein, smad2 Protein, smad2.S Protein, Smad2 Protein
- 背景
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Background: Mothers against decapentaplegic homolog 2(SMAD2) is a cytoplasm protein which belongs to the dwarfin/SMAD family. Smad proteins undergo rapid nuclear translocation upon stimulation by transforming growth factor and in so doing transduce the signal into the nucleus. Receptor-regulated SMAD is an intracellular signal transducer and transcriptional modulator activated by TGF-beta and activin type 1 receptor kinases. SMAD2 is contains 1 MH1 (MAD homology 1) domain and1 MH2 (MAD homology 2) domain. It is expressed at high levels in skeletal muscle, endothelial cells, heart and placenta. It binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. It may act as a tumor suppressor in colorectal carcinoma. And SMAD2 positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Synonym: Mothers against decapentaplegic homolog 2, MAD homolog 2, Mad-related protein 2, hMAD-2, SMAD family member 2, SMAD 2, Smad2, Hsmad2, SMAD2, MADH2, MADR2
- 分子量
- 54.6 kDa
- UniProt
- Q15796
- 途径
- Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
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