SLAMF7 Protein (His tag)
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- 抗原 See all SLAMF7 蛋白
- SLAMF7 (SLAM Family Member 7 (SLAMF7))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 小鼠
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资源
- HEK-293 Cells
- 标记
- This SLAMF7 protein is labelled with His tag.
- 原理
- Recombinant Mouse SLAMF7/CD319 Protein (His Tag)(Active)
- 序列
- Met 1-Gly 224
- 产品特性
- A DNA sequence encoding the mouse SLAMF7 (NP_653122.2) extracellular domain (Met 1-Gly 224) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by SDS-PAGE
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to bind biotinylated mouse SLAMF7 in a functional ELISA.
- Top Product
- Discover our top product SLAMF7 蛋白
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SLAM Family Member 7 (SLAMF7) (AA 23-226) protein (Fc Tag)
SLAMF7 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 7 (SLAMF7) (AA 23-226) protein (His-Avi Tag)SLAMF7 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 7 (SLAMF7) (AA 23-226) protein (mFc Tag)SLAMF7 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 7 (SLAMF7) (AA 23-226) protein (His-Avi Tag,Biotin)SLAMF7 宿主: 人 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 7 (SLAMF7) (AA 23-224) protein (His tag)SLAMF7 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 7 (SLAMF7) (AA 23-226) protein (His tag)SLAMF7 宿主: Cynomolgus 宿主: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
SLAM Family Member 7 (SLAMF7) (AA 23-226) protein (His tag)SLAMF7 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
SLAM Family Member 7 (SLAMF7) (AA 23-226) protein (His tag,AVI tag,Biotin)SLAMF7 宿主: 人 宿主: HEK-293 Cells Recombinant >95 % as determined by reduced SDS-PAGE.
SLAM Family Member 7 (SLAMF7) (AA 23-224) protein (His tag)SLAMF7 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
SLAM Family Member 7 (SLAMF7) protein (His tag)SLAMF7 宿主: 猕猴 宿主: 人细胞 Recombinant >95 % as determined by reducing SDS-PAGE.
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SLAMF7 (SLAM Family Member 7 (SLAMF7))
- 别名
- SLAMF7/CD319 (SLAMF7 产品)
- 别名
- RGD1560190 Protein, SLAMF7 Protein, slaf7 Protein, 19A Protein, CD319 Protein, CRACC Protein, CS1 Protein, 19A24 Protein, 4930560D03Rik Protein, SLAM family member 7 Protein, Slamf7 Protein, SLAMF7 Protein, slaf7 Protein
- 背景
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Background: SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruite signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
Synonym: SLAM family member 7, Leukocyte cell-surface antigen, Novel Ly9, CD319, Slamf7, CRACC,19A, 19A24, 4930560D03Rik, CRACCl, CS1
- 分子量
- 23.7 kDa
- NCBI登录号
- NP_653122
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