STAT6 Protein (His tag)
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- 抗原 See all STAT6 蛋白
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌(E. Coli)
- 标记
- This STAT6 protein is labelled with His tag.
- 原理
- Recombinant Human STAT6 Protein (E.coli, His Tag)
- 序列
- Ser627-Ser837
- 产品特性
- Recombinant Human STAT6 is produced by our E.coli expression system and the target gene encoding Ser627-Ser837 is expressed with a 6His tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product STAT6 蛋白
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
- 别名
- STAT6 (STAT6 产品)
- 别名
- D12S1644 Protein, IL-4-STAT Protein, STAT6B Protein, STAT6C Protein, signal transducer and activator of transcription 6 Protein, signal transducer and activator of transcription 6-like Protein, STAT6 Protein, Stat6 Protein, LOC100859543 Protein
- 背景
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Background: Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. STAT6 plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. STAT6 has been shown to interact with EP300, CREB-binding protein, NFKB1, Nuclear receptor coactivator 1, IRF4 and SND1.
Synonym: Signal Transducer and Activator of Transcription 6, IL-4 Stat, STAT6,IL-4-STAT,STAT6B,STAT6C
- 分子量
- 23.9 kDa
- UniProt
- P42226
- 途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
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