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STAT6 产品

(Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))

Categories

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010].

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Featured STAT6 Categories

STAT6 抗体

High quality antibodies with extensive validation data.

STAT6 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

STAT6 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended STAT6 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (6)
Cat. No. ABIN563038
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IP, ICC, IF
Validations
  • (5)
Cat. No. ABIN6255720
Quantity 100 μL
Datasheet Datasheet

Application WB, IHC, IHC (p)
Validations
  • (5)
Cat. No. ABIN6745701
Quantity 100 μL
Datasheet Datasheet

Recommended STAT6 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Semi-Quantitative Cell ELISA
Validations
  • (1)
  • (5)
Cat. No. ABIN1981845
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
Cat. No. ABIN1981731
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
  • (3)
Cat. No. ABIN4889794
Quantity 96 tests
Datasheet Datasheet

Recommended STAT6 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125097
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7125096
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321608
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our STAT6 Products

Hu, Marshall, Darby, Wei, Lyons, Körner: "Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with Leishmania major." in: Frontiers in immunology, Vol. 9, pp. 1, (2019) (PubMed).

Liu, Li, Liang, Li, Jiang, Chu, Yang: "Hydrogen sulfide attenuates myocardial fibrosis in diabetic rats through the JAK/STAT signaling pathway." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 1867-1876, (2018) (PubMed).

Chen, Zuo, Tang, Zuo, Jia, Liu, Liu, Zhu, Wang, Zhang, Shen, Chen, Yuan, Qin, Ruan, Ye, Wang, Zhou, Gao, Zhang, Liu, Jing, Lu, Yu: "Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice." in: The Journal of experimental medicine, Vol. 215, Issue 8, pp. 2175-2195, (2018) (PubMed).

Kong, Li, Shen, Liu, Zuo, Tao, Ji, Lu, Lazarus, Breyer, Yu: "Niacin Promotes Cardiac Healing after Myocardial Infarction through Activation of the Myeloid Prostaglandin D2 Receptor Subtype 1." in: The Journal of pharmacology and experimental therapeutics, Vol. 360, Issue 3, pp. 435-444, (2017) (PubMed).

Shen, Li, You, Wu, Wu, Zhao, Zhu, Guo, Li, Li, Ma, Yang, Chen: "Oral exposure to diisodecyl phthalate aggravates allergic dermatitis by oxidative stress and enhancement of thymic stromal lymphopoietin." in: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, Vol. 99, pp. 60-69, (2017) (PubMed).

Chen, Tian, Mei, Wang, Yao, Zhang, Li, Wang, Zhang, Xie: "The effect of the TLR9 ligand CpG-oligodeoxynucleotide on the protective immune response to radiation-induced lung fibrosis in mice." in: Molecular immunology, Vol. 80, pp. 33-40, (2017) (PubMed).

Chen, Wang, Mei, Zhang, Yang, Li, Yao, Xie: "Radiation-induced lung fibrosis in a tumor-bearing mouse model is associated with enhanced Type-2 immunity." in: Journal of radiation research, Vol. 57, Issue 2, pp. 133-41, (2017) (PubMed).

Onderdijk, Baerveldt, Kurek, Kant, Florencia, Debets, Prens: "IL-4 Downregulates IL-1β and IL-6 and Induces GATA3 in Psoriatic Epidermal Cells: Route of Action of a Th2 Cytokine." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 4, pp. 1744-52, (2015) (PubMed).

Dokduang, Techasen, Namwat, Khuntikeo, Pairojkul, Murakami, Loilome, Yongvanit: "STATs profiling reveals predominantly-activated STAT3 in cholangiocarcinoma genesis and progression." in: Journal of hepato-biliary-pancreatic sciences, Vol. 21, Issue 10, pp. 767-76, (2014) (PubMed).

Li, Guan, Liu: "The role of STAT-6 as a key transcription regulator in HeLa cell death induced by IFN-?/TNF-? co-immobilized on nanoparticles." in: Biomaterials, Vol. 35, Issue 18, pp. 5016-27, (2014) (PubMed).

Synonyms and alternative names related to STAT6

signal transducer and activator of transcription 6 (STAT6), signal transducer and activator of transcription 6 (Stat6), signal transducer and activator of transcription 6-like (LOC100859543), D12S1644, IL-4-STAT, STAT6B, STAT6C

Protein level used designations for STAT6

  • signal transducer and transcription activator 6
  • STAT, interleukin4-induced
  • signal transducer and activator of transcription 6
  • transcription factor IL-4 STAT
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