SERPINB9 Protein (His tag)
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- 抗原 See all SERPINB9 蛋白
- SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))
- 蛋白类型
- Recombinant
- 宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This SERPINB9 protein is labelled with His tag.
- 原理
- Recombinant Human SERPINB9/PI-9 Protein (Baculovirus, His Tag)
- 序列
- Glu 2-Pro 376
- 产品特性
- A DNA sequence encoding the human SERPINB9 (P50453) (Glu 2-Pro 376) was expressed, with a polyhistidine tag at the N-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
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- Discover our top product SERPINB9 蛋白
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serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) (AA 66-328) protein (His tag)
SERPINB9 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) (AA 279-375) protein (GST tag)SERPINB9 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) (AA 1-376) protein (GST tag)SERPINB9 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) protein (Myc-DYKDDDDK Tag)SERPINB9 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 50 mM Tris, 100 mM NaCl, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SERPINB9 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9))
- 别名
- SERPINB9/PI-9 (SERPINB9 产品)
- 别名
- SERPINB9 Protein, BB283241 Protein, CAP-3 Protein, CAP3 Protein, PI-9 Protein, PI9 Protein, Spi6 Protein, ovalbumin Protein, serpin family B member 9 Protein, serpin peptidase inhibitor, clade B (ovalbumin), member 9 Protein, serine (or cysteine) peptidase inhibitor, clade B, member 9 Protein, Serpinb9 Protein, SERPINB9 Protein
- 背景
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Background: SerpinB9; also known as Cytoplasmic antiproteinase 3; CAP-3; Peptidase inhibitor 9; SERPINB9 and PI-9; is a cytoplasm protein which belongs to the serpin family and Ov-serpin subfamily. Serpin-B9 ( CAP-3 / PI-9 ) is the only known human intracellular inhibitor of granzyme B (GrB); the effector molecule in immunity against cytomegalovirus (CMV) and in renal allograft rejection. Serpin-B9 and SPI-6 expression in immune-privileged cells; APCs; and CTLs protects these cells against the actions of granzyme B; and when expressed in tumor cells or virally infected hepatocytes; confers resistance to killing by CTL and NK cells. Expression of increasing levels of Serpin-B9 ( CAP-3 / PI-9 ) in target cells may progressively inhibit immune surveillance by blocking NK and CTL-induced cytotoxicity through the perforin / granzyme pathway and then through the Fas / FasL pathway. Serpin-B9 ( CAP-3 / PI-9 ) is selectively up-regulated in hepatocytes in response to infiltration of the liver by NK cells that express perforin and enzymatically active granzyme B. Upregulated expression of Serpin-B9 ( CAP-3 / PI-9 ) in NSCLC cells may serve to protect them from apoptosis induced by GrB.
Synonym: Cytoplasmic antiproteinase 3;Peptidase inhibitor 9;CAP3;PI-9;Serpin B9
- 分子量
- 44.5 kDa
- UniProt
- P50453
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