SERPINB3 Protein (His tag)
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- 抗原 See all SERPINB3 蛋白
- SERPINB3 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 标记
- This SERPINB3 protein is labelled with His tag.
- 原理
- Recombinant Human SerpinB3/SCCA1 Protein (His Tag)(Active)
- 序列
- Asn 2-Pro 390
- 产品特性
- A DNA sequence encoding the human SERPINB3 (AAB20405.1) (Asn 2-Pro 390) was expressed, with a polyhistidine tag at the N-terminus.
- 纯度
- > 97 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to inhibit active Cathepsin L cleavage of a fluorogenice peptide substrate Z-LR-AMC, R&D Systems, Catalog # ES008.The IC50 is < 5 nM.
- Top Product
- Discover our top product SERPINB3 蛋白
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serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3) (AA 276-390) protein (GST tag)
SERPINB3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3) (AA 1-390) protein (His tag)SERPINB3 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3) (AA 1-390) protein (GST tag)SERPINB3 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3) protein (His tag)SERPINB3 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 95 % as determined by SDS-PAGE
serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3) protein (Myc-DYKDDDDK Tag)SERPINB3 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 20 % glycerol, 3 mM DTT
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- SERPINB3 (serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 3 (SERPINB3))
- 别名
- SerpinB3/SCCA1 (SERPINB3 产品)
- 别名
- HsT1196 Protein, SCC Protein, SCCA-1 Protein, SCCA-PD Protein, SCCA1 Protein, T4-A Protein, LEUPIN Protein, PI11 Protein, SCCA-2 Protein, SCCA2 Protein, serpin family B member 3 Protein, serpin family B member 4 Protein, serpin B3 Protein, Somatic cell count Protein, SERPINB3 Protein, SERPINB4 Protein, Serpinb3 Protein, LOC483954 Protein, SCC Protein
- 背景
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Background: SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be secreted in plasma by cancerous cells but at a low level. SERPINB3 significantly attenuates apoptosis by contrasting cytochrome c release from the mitochondria and by antichemotactic effect for NK cells. It may act as a protease inhibitor to modulate the host immune response against tumor cells and may be involved in the malignant behavior of squamous cell carcinoma cells.
Synonym: Serpin B3, Protein T4-A, Squamous cell carcinoma antigen 1, SCCA-1,serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3, serpin peptidase inhibitor, clade B (ovalbumin), member 3, Squamous cell carcinoma antigen 1,T4-A,SCCA1,HsT1196,SCC,SCCA-1,SCCA-PD
- 分子量
- 46.7 kDa
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