PTPN2 蛋白
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- 抗原 See all PTPN2 蛋白
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
- 蛋白类型
- Recombinant
- 生物活性
- Active
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宿主
- 人
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资源
- Baculovirus infected Insect Cells
- 原理
- Recombinant Human PTPN2/PTPT Protein (Active)
- 序列
- Met 1-Asn 314
- 产品特性
- A DNA sequence encoding the human PTPN2 (?P17706-1) (Met 1-Asn 314) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate, R&D Systems, Catalog # ES006.The specific activity is > 30 μmoles/min/mg.
- Top Product
- Discover our top product PTPN2 蛋白
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Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 1-387) protein (GST tag)
PTPN2 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) protein (His tag)PTPN2 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by reducing SDS-PAGE.
Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 2-314) (Active) protein (His tag)PTPN2 宿主: 小鼠 宿主: Baculovirus infected Insect Cells Recombinant > 90 % as determined by SDS-PAGE Active
Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 1-415) protein (Strep Tag)Crystallography grade PTPN2 宿主: 人 宿主: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (AA 1-406) protein (Strep Tag)Crystallography grade PTPN2 宿主: 小鼠 宿主: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA
Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2) (Transcript Variant 3) protein (Myc-DYKDDDDK Tag)PTPN2 宿主: 人 宿主: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 500 mM NaCl, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PTPN2 (Protein tyrosine Phosphatase, Non-Receptor Type 2 (PTPN2))
- 别名
- PTPN2/PTPT (PTPN2 产品)
- 别名
- PTN2 Protein, PTPT Protein, TC-PTP Protein, TCELLPTP Protein, TCPTP Protein, AI325124 Protein, Ptpt Protein, PTP-1B Protein, cb806 Protein, ptpn2 Protein, ptpn2l Protein, wu:fc10h07 Protein, zgc:55339 Protein, zgc:76973 Protein, hm:zeh1546 Protein, zgc:63623 Protein, ptn2 Protein, ptpt Protein, tc-ptp Protein, tcellptp Protein, tcptp Protein, protein tyrosine phosphatase, non-receptor type 2 Protein, protein tyrosine phosphatase, non-receptor type 2 S homeolog Protein, protein tyrosine phosphatase, non-receptor type 2, b Protein, protein tyrosine phosphatase, non-receptor type 2, a Protein, protein tyrosine phosphatase, non-receptor type 2 L homeolog Protein, PTPN2 Protein, Ptpn2 Protein, ptpn2.S Protein, ptpn2b Protein, ptpn2a Protein, ptpn2.L Protein
- 背景
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Background: Tyrosine-protein phosphatase non-receptor type 2; also known as T-cell protein-tyrosine phosphatase; PTPN2 and PTPT; is a cytoplasm protein which belongs to the protein-tyrosine phosphatase family and Non-receptor class 1 subfamily. Members of the protein tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif; which is essential for the catalytic activity. TC-PTP / PTPN2 is a cytosolic tyrosine phosphatase that functions as a negative regulator of a variety of tyrosine kinases and other signaling proteins. The expression of TC-PTP / PTPN2 plays a role of tumor suppressor and may modulate response to treatment. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth; differentiation; mitotic cycle; and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP; which suggested the roles in growth factor mediated cell signaling. TC-PTP / PTPN2 is an enzyme that is essential for the proper functioning of the immune system and that participates in the control of cell proliferation; and inflammation. TC-PTP / PTPN2 was identified as a negative regulator of NUP214-ABL1 kinase activity.
Synonym: PTN2;PTPT;TC-PTP;TCELLPTP;TCPTP
- 分子量
- 36.8 kDa
- 途径
- EGFR Signaling Pathway, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling
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