PCSK1 Protein (His tag)
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- 抗原 See all PCSK1 蛋白
- PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- HEK-293 Cells
- 标记
- This PCSK1 protein is labelled with His tag.
- 原理
- Recombinant Human PCSK1/NEC1 Protein (His Tag)
- 序列
- Met 1-Arg 617
- 产品特性
- A DNA sequence encoding the human PCSK1 (NP_000430.3) (Met 1-Arg 617) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- 内毒素水平
- < 1.0 EU per μg as determined by the LAL method.
- Top Product
- Discover our top product PCSK1 蛋白
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Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 652-753) protein (GST tag)
PCSK1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 111-753) protein (His tag)Crystallography grade PCSK1 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1) (AA 111-753) protein (His tag)Crystallography grade PCSK1 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 25 mM Tris, 150 mM NaCl, pH 7.5
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PCSK1 (Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
- 别名
- PCSK1/NEC1 (PCSK1 产品)
- 别名
- BMIQ12 Protein, NEC1 Protein, PC1 Protein, PC3 Protein, SPC3 Protein, Nec-1 Protein, Nec1 Protein, Phpp-1 Protein, BDP Protein, PC1/3 Protein, proprotein convertase subtilisin/kexin type 1 Protein, prohormone convertase 1 Protein, PCSK1 Protein, Pcsk1 Protein, pcsk1 Protein, PC1B Protein
- 背景
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Background: Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleave after a single arginine. It binds to a protein known as proSAAS, which also represents its endogenous inhibitor. PCSK1 is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. PCSK1 substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin. Defects in PCSK1 are the cause of proprotein convertase 1 deficiency (PC1 deficiency). PC1 deficiency is characterized by obesity, hypogonadism, hypoadrenalism, reactive hypoglycemia as well as marked small-intestinal absorptive dysfunction. It is due to impaired processing of prohormones.
Synonym: BMIQ12;NEC1;PC1;PC3;SPC3
- 分子量
- 57.4 kDa
- NCBI登录号
- NP_000430
- 途径
- Peptide Hormone Metabolism
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