PIN1 Protein (His tag)
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- 抗原 See all PIN1 蛋白
- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PIN1 protein is labelled with His tag.
- 原理
- Recombinant Human PIN1/Rotamase Pin1 Protein (His Tag)
- 序列
- Met 1-Glu 163
- 产品特性
- A DNA sequence encoding the mature form of human PIN1 (Q13526-1) (Met 1-Glu 163) was expressed, with a polyhistide tag at the N-terminus.
- 纯度
- > 90 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product PIN1 蛋白
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Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) protein
PIN1 宿主: 人 宿主: 大肠杆菌（E. Coli） 95 % by SDS - PAGE SDS
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) protein (His tag)PIN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) (Active) proteinPIN1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant SDS, Func Active
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 1-163) protein (GST tag)PIN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1) (AA 64-163) protein (GST tag)PIN1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile PBS, pH 7.4
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
- 别名
- PIN1/Rotamase Pin1 (PIN1 产品)
- 别名
- DOD Protein, UBL5 Protein, dod Protein, ubl5 Protein, pin1 Protein, pin1a Protein, 0610025L01Rik Protein, D9Bwg1161e Protein, pin1b Protein, zgc:73206 Protein, PPIase pin1 Protein, MdPin1 Protein, Pin1 Protein, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Protein, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog Protein, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 Protein, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog Protein, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Protein, peptidyl-prolyl cis-trans isomerase Pin1 Protein, PIN1 Protein, Pin1 Protein, pin1 Protein, pin1.S Protein, pin1.L Protein, ppiD Protein, PITG_11123 Protein, LOC103419188 Protein
- 背景
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Background: Peptidyl-prolyl cis-trans isomerase Pin1, also known as Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, Rotamase Pin1 and PIN1, peptidyl-prolyl cis/trans isomerase (PPIase), is a nucleus protein. PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and so affect protein function and/or stability. PIN1 regulates a number of proteins important for cell-cycle progression and is presumed to operate as a molecular timer of this important process. PIN1 is an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. PIN1 displays a preference for an acidic residue N-terminal to the isomerized proline bond. Alterations in the level of PIN1 can influence hyperproliferative diseases such as cancer. PIN1 has been implicated in multiple aspects of cell cycle regulation. It has been suggested that PIN1 function is required for both normal mitotic progression and reentry into the cell cycle from quiescence. PIN1 is also a target of several oncogenic pathways and is overexpressed in human breast cancer. Its overexpression can lead to upregulation of cyclin-D1 and transformation of breast epithelial cells in collaboration with the oncogenic pathways. PIN1 plays a pivotal role in breast development and may be a promising new anticancer target. Pin1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. Recent data also implicate Pin1 as playing an important role in immune responses, at least in part by increasing the stability of cytokine mRNAs by influencing the protein complexes to which they bind.
Synonym: DOD,UBL5
- 分子量
- 20.3 kDa
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