PIN1 产品
(Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
Categories
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011].
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Featured PIN1 Categories
PIN1 抗体
High quality antibodies with extensive validation data.
PIN1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
PIN1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PIN1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF, FACS
Validations
- (9)
Cat. No.
ABIN3028920
Quantity
0.4 mL
Datasheet
Datasheet
Reactivity
Human
Application
WB
Validations
- (4)
Cat. No.
ABIN3022930
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF, FACS, IHC (p)
Validations
- (5)
Cat. No.
ABIN652906
Quantity
400 μL
Datasheet
Datasheet
Recommended PIN1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6974378
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6969199
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6958454
Quantity
96 tests
Datasheet
Datasheet
Recommended PIN1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124343
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN5570392
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PIN1 Products
: "Pin1 and secondary hyperparathyroidism of chronic kidney disease: gene polymorphisms and protein levels." in: Renal failure, Vol. 39, Issue 1, pp. 159-165, (2017) (PubMed).: "Pin1 regulates osteoclast fusion through suppression of the master regulator of cell fusion DC-STAMP." in: Journal of cellular physiology, Vol. 229, Issue 12, pp. 2166-74, (2014) (PubMed).
: "Pin1 plays a critical role as a molecular switch in canonical BMP signaling." in: Journal of cellular physiology, Vol. 230, Issue 3, pp. 640-7, (2014) (PubMed).
: "Regulation of the microRNA 200b (miRNA-200b) by transcriptional regulators PEA3 and ELK-1 protein affects expression of Pin1 protein to control anoikis." in: The Journal of biological chemistry, Vol. 288, Issue 45, pp. 32742-52, (2013) (PubMed).
: "The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer." in: PLoS ONE, Vol. 8, Issue 2, pp. e55355, (2013) (PubMed).
: "Androgen receptor serine 81 mediates Pin1 interaction and activity." in: Cell cycle (Georgetown, Tex.), Vol. 11, Issue 18, pp. 3415-20, (2013) (PubMed).
: "Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1." in: Cell death and differentiation, Vol. 19, Issue 7, pp. 1152-61, (2012) (PubMed).
: "Pin1 interacts with c-Myb in a phosphorylation-dependent manner and regulates its transactivation activity." in: Biochimica et biophysica acta, Vol. 1783, Issue 6, pp. 1121-8, (2008) (PubMed).
: "Pin1 promotes cell death in NGF-dependent neurons through a mechanism requiring c-Jun activity." in: Journal of neurochemistry, Vol. 106, Issue 2, pp. 734-45, (2008) (PubMed).
: "Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy." in: The Journal of clinical investigation, Vol. 118, Issue 5, pp. 1877-89, (2008) (PubMed).
Synonyms and alternative names related to PIN1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1), peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (Pin1), peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (pin1), peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog (pin1.S), protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (Pin1), peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog (pin1.L), peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (ppiD), peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PITG_11123), peptidyl-prolyl cis-trans isomerase Pin1 (pin1), peptidyl-prolyl cis-trans isomerase Pin1 (LOC103419188), 0610025L01Rik, D9Bwg1161e, DOD, dod, MdPin1, pin1, Pin1, pin1a, pin1b, PPIase pin1, UBL5, ubl5, zgc:73206Protein level used designations for PIN1
- PPIase Pin1
- peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
- protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
- rotamase Pin1
- protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1
- prolyl isomerase Pin1
- peptidylprolyl cis/trans isomerase, NIMA-interacting 1 a
- peptidyl-prolyl cis-trans isomerase Pin1
- prolyl isomerase Pin1 b
- peptidylprolyl cis/trans isomerase, NIMA-interacting 1 b
- Pin1-type peptidyl-prolyl cis/trans isomerase
- Rotamase Pin1
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