PARK7/DJ1 Protein (His tag)
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- 抗原 See all PARK7/DJ1 (PARK7) 蛋白
- PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This PARK7/DJ1 protein is labelled with His tag.
- 原理
- Recombinant Human PARK7/DJ-1 Protein (His Tag)
- 序列
- Met 1-Asp 189
- 产品特性
- A DNA sequence encoding the human PARK7 (Q99497-1) (Met 1-Asp 189) was fused with a polyhistidine tag at the C-terminus.
- 纯度
- > 95 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product PARK7 蛋白
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Parkinson Protein 7 (PARK7) (AA 1-189) protein (GST tag)
PARK7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Parkinson Protein 7 (PARK7) (AA 1-100) protein (GST tag)PARK7 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Parkinson Protein 7 (PARK7) (AA 1-188), (partial) protein (GST tag)PARK7 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95 % ELISA
Parkinson Protein 7 (PARK7) proteinPARK7 宿主: 大鼠 宿主: 大肠杆菌（E. Coli） Recombinant > 97 % SDS, WB, ELISA, IP
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Please refer to the printed manual for detailed information.
- 缓冲液
- Lyophilized from sterile 20 mM Tris, 150 mM NaCl, 3 mM DTT, 5 % glycerol, pH 8.0
- 储存条件
- 4 °C,-20 °C,-80 °C
- 储存方法
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- 抗原
- PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))
- 别名
- PARK7/DJ-1 (PARK7 产品)
- 别名
- DJ-1 Protein, DJ1 Protein, CAP1 Protein, Dj1 Protein, SP22 Protein, dj1 Protein, zgc:103725 Protein, park7b Protein, park7 Protein, park7a Protein, Parkinsonism associated deglycase Protein, Parkinson disease (autosomal recessive, early onset) 7 Protein, parkinson protein 7 Protein, parkinson protein 7 S homeolog Protein, parkinson protein 7 L homeolog Protein, PARK7 Protein, Park7 Protein, park7 Protein, park7.S Protein, park7.L Protein
- 背景
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Background: Parkinson's disease locus DJ-1 (PARK7) is a differentially expressed transcript. DJ-1 plays a physiologic role in protection of erythroid cells from oxidant damage, a function unmasked in the context of oxidative stress. PARK7 belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Mutations in the DJ-1 gene are associated with rare forms of autosomal recessive early-onset Parkinson's disease (PD). DJ-1/p53 interactions contribute to apoptosis resistance in clonal myeloid cells and may serve as a prognostic marker in patients with myelodysplastic syndromes (MDS). DJ-1 regulates redox signaling kinase pathways and acts as a transcriptional regulator of antioxidative gene batteries. Therefore, DJ-1 is an important redox-reactive signaling intermediate controlling oxidative stress after ischemia, upon neuroinflammation, and during age-related neurodegenerative processes. Augmenting DJ-1 activity might provide novel approaches to treating chronic neurodegenerative illnesses such as Parkinson's disease and acute damage such as stroke.
Synonym: DJ-1,DJ1,HEL-S-67p
- 分子量
- 21.3 kDa
- 途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport
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