NME1 Protein (His tag)
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- 抗原 See all NME1 蛋白
- NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))
- 蛋白类型
- Recombinant
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宿主
- 人
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资源
- 大肠杆菌（E. Coli）
- 标记
- This NME1 protein is labelled with His tag.
- 原理
- Recombinant Human NME1/NDKA Protein (His Tag)
- 序列
- Ala 2-Glu 152
- 产品特性
- A DNA sequence encoding the human NME1 isoform b (NP_000260.1) (Ala 2-Glu 152) was expressed, with a polyhistide tag at the N-terminus.
- 纯度
- > 98 % as determined by reducing SDS-PAGE.
- Top Product
- Discover our top product NME1 蛋白
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Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 1-152) protein (GST tag)
NME1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 43-152) protein (GST tag)NME1 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 2-152) protein (His tag)Crystallography grade NME1 宿主: 小鼠 宿主: 大肠杆菌（E. Coli） Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 2-152) protein (His tag)NME1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant >98 % as determined by SDS-PAGE.
Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (Transcript Variant 2) protein (His tag)NME1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant > 95 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1) (AA 2-152), (full length) protein (GST tag)NME1 宿主: 人 宿主: 大肠杆菌（E. Coli） Recombinant 95 % SDS, WB, ELISA
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- 限制
- 仅限研究用
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- 状态
- Frozen, Liquid
- 缓冲液
- Supplied as sterile PBS, pH 7.4
- 储存条件
- -20 °C
- 储存方法
- Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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- 抗原
- NME1 (Non-Metastatic Cells 1, Protein (NM23A) Expressed in (NME1))
- 别名
- NME1/NDKA (NME1 产品)
- 别名
- AWD Protein, GAAD Protein, NB Protein, NBS Protein, NDKA Protein, NDPK-A Protein, NDPKA Protein, NM23 Protein, NM23-H1 Protein, AL024257 Protein, NM23-M1 Protein, NM23A Protein, NDPK-Z1 Protein, NM23-B Protein, NM23-Z1 Protein, ndpkz1 Protein, nm23b Protein, nme1 Protein, nme2 Protein, nme2b1 Protein, NME1 Protein, NME1-NME2 Protein, NM23-C1 Protein, ndpk-b Protein, ndpkb Protein, nm23-h2 Protein, nm23ndk Protein, puf Protein, NBR-A Protein, NBR-B Protein, NME1-1 Protein, nm23ndk-a Protein, NDK I Protein, NDPK I Protein, T30A10.80 Protein, T30A10_80 Protein, NDP kinase I Protein, NME/NM23 nucleoside diphosphate kinase 1 Protein, NME/NM23 nucleoside diphosphate kinase 2b, tandem duplicate 1 Protein, non-metastatic cells 1, protein (NM23A) expressed in Protein, NME/NM23 nucleoside diphosphate kinase 2 S homeolog Protein, NME/NM23 nucleoside diphosphate kinase 2 L homeolog Protein, nucleoside diphosphate kinase Protein, nucleoside diphosphate kinase 1 Protein, NME1 Protein, Nme1 Protein, nme2b.1 Protein, nme2.S Protein, nme2.L Protein, LOC547870 Protein, NDPK1 Protein, LOC107790563 Protein
- 背景
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Background: NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate the cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of NM23-H1. As a result, the interactions with NM23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis. NDKA is increased in human postmortem cerebrospinal fluid (CSF), a model of global brain insult, suggesting that measurement in CSF and, more importantly, in plasma may be useful as a biomarker of stroke. Additionally, NM23-H1 significantly reduces metastasis without effects on primary tumor size and was the first discovered metastasis suppressor gene.
Synonym: Nucleoside Diphosphate Kinase A, NDK A, NDP Kinase A, Granzyme A-Activated DNase, GAAD, Metastasis Inhibition Factor nm23, Tumor Metastatic Process-Associated Protein, nm23-H1, NME1, NDPKA, NM23,AWD,GAAD,NB,NBS,NDKA,NDPK-A,NM23-H1
- 分子量
- 18 kDa
- NCBI登录号
- NP_000260
- 途径
- Apoptosis, Nucleotide Phosphorylation, Carbohydrate Homeostasis, Ribonucleoside Biosynthetic Process
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